4D Printing: The Development of Responsive Materials Using 3D-Printing Technology

Author:

Antezana Pablo Edmundo12,Municoy Sofia1ORCID,Ostapchuk Gabriel34ORCID,Catalano Paolo Nicolás345,Hardy John G.67ORCID,Evelson Pablo Andrés2ORCID,Orive Gorka891011ORCID,Desimone Martin Federico1ORCID

Affiliation:

1. Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de la Química y Metabolismo del Fármaco (IQUIMEFA), Facultad de Farmacia y Bioquímica Junín 956, Piso 3, Buenos Aires 1113, Argentina

2. Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Bioquímica y Medicina Molecular (IBIMOL), Facultad de Farmacia y Bioquímica, Buenos Aires 1428, Argentina

3. Instituto de Nanociencia y Nanotecnología (CNEA-CONICET), Nodo Constituyentes, Av. Gral. Paz 1499 (B1650KNA), San Martín, Buenos Aires 8400, Argentina

4. Departamento de Micro y Nanotecnología, Gerencia de Desarrollo Tecnológico y Proyectos Especiales, Gerencia de Área de Investigación, Desarrollo e Innovación, Centro Atómico Constituyentes, Comisión Nacional de Energía Atómica, Av. Gral. Paz 1499 (B1650KNA), San Martín, Buenos Aires 8400, Argentina

5. Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Ciencias Químicas, Cátedra de Química Analítica Instrumental, Junín 954, Buenos Aires 1113, Argentina

6. Materials Science Institute, Lancaster University, Lancaster LA1 4YB, UK

7. Department of Chemistry, Faraday Building, Lancaster University, Lancaster LA1 4YB, UK

8. NanoBioCel Research Group, School of Pharmacy, University of the Basque Country (UPV/EHU), 01006 Vitoria-Gasteiz, Spain

9. Bioaraba, NanoBioCel Research Group, 01009 Vitoria-Gasteiz, Spain

10. Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Institute of Health Carlos III, Av Monforte de Lemos 3-5, 28029 Madrid, Spain

11. University Institute for Regenerative Medicine and Oral Implantology—UIRMI (UPV/EHU-Fundación Eduardo Anitua), 01007 Vitoria-Gasteiz, Spain

Abstract

Additive manufacturing, widely known as 3D printing, has revolutionized the production of biomaterials. While conventional 3D-printed structures are perceived as static, 4D printing introduces the ability to fabricate materials capable of self-transforming their configuration or function over time in response to external stimuli such as temperature, light, or electric field. This transformative technology has garnered significant attention in the field of biomedical engineering due to its potential to address limitations associated with traditional therapies. Here, we delve into an in-depth review of 4D-printing systems, exploring their diverse biomedical applications and meticulously evaluating their advantages and disadvantages. We emphasize the novelty of this review paper by highlighting the latest advancements and emerging trends in 4D-printing technology, particularly in the context of biomedical applications.

Funder

Universidad de Buenos Aires

UBACYT

PIDAE

CONICET PIP

PIBAA

Publisher

MDPI AG

Subject

Pharmaceutical Science

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