Long-Acting Injectable Antipsychotics—A Review on Formulation and In Vitro Dissolution

Author:

Markowicz-Piasecka Magdalena1ORCID,Kubisiak Marcin2,Asendrych-Wicik Katarzyna23,Kołodziejczyk Michał4,Grzelińska Joanna2,Fabijańska Małgorzata5ORCID,Pietrzak Tomasz26ORCID

Affiliation:

1. Department of Applied Pharmacy, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz, Poland

2. Liquid Dosage Form Laboratory, Research and Development Department, Polfa Warszawa S.A., Karolkowa 22/24, 01-207 Warsaw, Poland

3. Department of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz, Poland

4. Department of Drug Form Technology, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz, Poland

5. Department of Bioinorganic Chemistry, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz, Poland

6. Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland

Abstract

Long-acting injectable (LAI) neuroleptics constitute an effective therapeutical alternative for individuals suffering from persistent mental illness. These injectable pharmaceuticals help patients manage their condition better and improve long-term outcomes by preventing relapses and improving compliance. This review aims to analyse the current formulation aspects of LAI neuroleptics, with particular emphasis on analysis of drug release profiles as a critical test to guarantee drug quality and relevant therapeutical activity. While there is no officially approved procedure for depot parenteral drug formulations, various dissolution tests which were developed by LAI manufacturers are described. In vitro dissolution tests also possess a critical function in the estimation of the in vivo performance of a drug formulation. For that reason, thorough inspection of the in vitro–in vivo correlation (IVIVC) is also discussed.

Funder

Medical University of Lodz

Polfa Warszawa S.A.

Publisher

MDPI AG

Subject

Pharmaceutical Science

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