Tracers for Cardiac Imaging: Targeting the Future of Viable Myocardium

Author:

Nappi Carmela1,Panico Mariarosaria2,Falzarano Maria1,Vallone Carlo1,Ponsiglione Andrea1ORCID,Cutillo Paolo1,Zampella Emilia1ORCID,Petretta Mario3ORCID,Cuocolo Alberto1ORCID

Affiliation:

1. Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy

2. Institute of Biostructure and Bioimaging, National Council of Research, 80131 Naples, Italy

3. IRCCS SYNLAB SDN, Via Gianturco 113, 80131 Naples, Italy

Abstract

Ischemic heart disease is the leading cause of mortality worldwide. In this context, myocardial viability is defined as the amount of myocardium that, despite contractile dysfunction, maintains metabolic and electrical function, having the potential for functional enhancement upon revascularization. Recent advances have improved methods to detect myocardial viability. The current paper summarizes the pathophysiological basis of the current methods used to detect myocardial viability in light of the advancements in the development of new radiotracers for cardiac imaging.

Publisher

MDPI AG

Subject

Pharmaceutical Science

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