Affiliation:
1. Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pẻcs, 7624 Pecs, Hungary
2. School of Science and Applied Technology, Laikipia University, Nyahururu P.O. Box 1100-20300, Kenya
3. Faculty of Health Sciences, University of Pẻcs, 7624 Pecs, Hungary
Abstract
Aloe species are widespread and diverse in African ecosystems, and this commonly correlates to their habitual use as reservoirs of herbal medicine. The side effects associated with chemotherapy and the development of antimicrobial resistance to empirically used antimicrobial drugs are substantial, paving the way for novel phytotherapeutic approaches. This comprehensive study aimed to evaluate and present Aloe secundiflora (A. secundiflora) as a compelling alternative with potential benefits in colorectal cancer (CRC) treatment. Important databases were systematically searched for relevant literature, and out of a large collection of 6421 titles and abstracts, only 68 full-text articles met the inclusion criteria. A. secundiflora possesses an abundant presence of bioactive phytoconstituents in the leaves and roots, including anthraquinones, naphthoquinones, phenols, alkaloids, saponins, tannins, and flavonoids, among others. These metabolites have proven diverse efficacy in inhibiting cancer growth. The presence of innumerable biomolecules in A. secundiflora signifies the beneficial effects of incorporating the plant as a potential anti-CRC agent. Nonetheless, we recommend further research to determine the optimal concentrations necessary to elicit beneficial effects in the management of CRC. Furthermore, they should be investigated as potential raw ingredients for making conventional medications.
Reference68 articles.
1. An analysis of the ethnoveterinary medicinal uses of the genus Aloe L. for animal diseases in Africa;Aremu;S. Afr. J. Bot.,2022
2. Cock, I.E. (2015). The Genus Aloe: Phytochemistry and Therapeutic Uses Including Treatments for Gastrointestinal Conditions and Chronic Inflammation, Springer Nature.
3. Reynolds, T. (2016). The Genus Aloe, CRC Press. [1st ed.].
4. Antimicrobial Properties of Aloe vera, Aloe volkensii and Aloe secundiflora from Egerton University;Waithaka;Acta Sci. Microbiol.,2018
5. Abdissa, N., Gohlke, S., Frese, M., and Sewald, N. (2017). Cytotoxic Compounds from Aloe megalacantha. Molecules, 22.
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献