Hydrodynamic Delivery: Characteristics, Applications, and Technological Advances-Reference-Cited by-同舟云学术

Hydrodynamic Delivery: Characteristics, Applications, and Technological Advances

Published:2023-03-31 Issue:4 Volume:15 Page:1111
ISSN:1999-4923
Container-title:Pharmaceutics
language:en
Short-container-title:Pharmaceutics

Author:

Suda Takeshi¹^ORCID,Yokoo Takeshi²^ORCID,Kanefuji Tsutomu³,Kamimura Kenya⁴^ORCID,Zhang Guisheng⁵,Liu Dexi⁵

Affiliation:

1. Department of Gastroenterology and Hepatology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Minamiuonuma 949-7302, Niigata, Japan

2. Department of Preemptive Medicine for Digestive Diseases and Healthy Active Life, School of Medicine, Niigata University, Niigata 951-8510, Niigata, Japan

3. Department of Gastroenterology and Hepatology, Tsubame Rosai Hospital, Tsubame 959-1228, Niigata, Japan

4. Department of General Medicine, School of Medicine, Niigata University, Niigata 951-8510, Niigata, Japan

5. Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30602, USA

Abstract

The principle of hydrodynamic delivery was initially used to develop a method for the delivery of plasmids into mouse hepatocytes through tail vein injection and has been expanded for use in the delivery of various biologically active materials to cells in various organs in a variety of animal species through systemic or local injection, resulting in significant advances in new applications and technological development. The development of regional hydrodynamic delivery directly supports successful gene delivery in large animals, including humans. This review summarizes the fundamentals of hydrodynamic delivery and the progress that has been made in its application. Recent progress in this field offers tantalizing prospects for the development of a new generation of technologies for broader application of hydrodynamic delivery.

Publisher

MDPI AG

Subject

Pharmaceutical Science

Link

https://www.mdpi.com/1999-4923/15/4/1111/pdf

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