Transcatheter Mitral Repair for Functional Mitral Regurgitation According to Left Ventricular Function: A Real-Life Propensity-Score Matched Study
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Published:2020-06-09
Issue:6
Volume:9
Page:1792
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ISSN:2077-0383
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Container-title:Journal of Clinical Medicine
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language:en
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Short-container-title:JCM
Author:
Pascual IsaacORCID, Carrasco-Chinchilla Fernando, Benito-Gonzalez TomasORCID, Li Chi HionORCID, Avanzas PabloORCID, Nombela-Franco Luis, Pan Manuel, Serrador Frutos Ana, Freixa Xavier, Trillo-Nouche Ramiro, Hernández-Antolín Rosa A., Andraka Ikazuriaga Leire, Cruz-Gonzalez Ignacio, López-Mínguez Jose R.ORCID, Diez Jose L.ORCID, Berenguer-Jofresa Alberto, Sanchis Juan, Ruiz-Quevedo Valeriano, Urbano-Carrillo Cristobal, Dominguez Juan F. Oteo, Ortas-Nadal Maria R., Molina Navarro Eduardo, Carrillo Xavier, Alonso-Briales Juan H., Fernández-Vázquez FelipeORCID, Asmarats Serra Luis, Hernandez-Vaquero DanielORCID, Jimenez-Quevedo Pilar, Mesa Dolores, Rodríguez-Gabella Tania, Regueiro Ander, Martinez Monzonís Amparo, Salido Tahoces Luisa, Ruiz Gomez Lara, Trejo-Velasco BlancaORCID, Becerra-Muñoz Victor M., Garrote-Coloma Carmen, Fernández Peregrina EstafaníaORCID, Lorca Rebeca, Agustín Jose A. De, Romero Miguel, Amat-Santos Ignacio J., Sabaté ManelORCID, Alvarez Ana B. Cid, Hernandez-Garcia Jose M., Gualis Javier, Arzamendi Dabit, Moris CesarORCID, Tirado-Conte Gabriela, Sánchez-Recalde Angel, Estevez-Loureiro Rodrigo
Abstract
Background: Transcatheter mitral valve repair (TMVR) could improve survival in functional mitral regurgitation (FMR), but it is necessary to consider the influence of left ventricular ejection fraction (LVEF). Therefore, we compare the outcomes after TMVR with Mitraclip® between two groups according to LVEF. Methods: In an observational registry study, we compared the outcomes in patients with FMR who underwent TMVR with and without LVEF <30%. The primary endpoint was the combined one-year all-cause mortality and unplanned hospital readmissions due to HF. The secondary end-points were New York Heart Association (NYHA) functional class and mitral regurgitation (MR) severity. Propensity-score matching was used to create two groups with the same baseline characteristics, except for baseline LVEF. Results: Among 535 FMR eligible patients, 144 patients with LVEF <30% (group 1) and 144 with LVEF >30% (group 2) had similar propensity scores and were included in the analyses. The primary study endpoint was significantlly higher in group 1 (33.3% vs. 9.4%, p = 0.002). There was a maintained improvement in secondary endpoints without significant differences among groups. Conclusion: FMR patients with LVEF <30% treated with MitraClip® had higher mortality and readmissions than patients with LVEF ≥30% treated with the same device. However, both groups improved the NYHA functional class and MR severity.
Cited by
4 articles.
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