Anti-Atopic Dermatitis Effect of TPS240, a Novel Therapeutic Peptide, via Suppression of NF-κB and STAT3 Activation
-
Published:2023-10-31
Issue:21
Volume:24
Page:15814
-
ISSN:1422-0067
-
Container-title:International Journal of Molecular Sciences
-
language:en
-
Short-container-title:IJMS
Author:
Lee Dongwoo1, Hwang-Bo Jeon1, Veerappan Karpagam1ORCID, Moon Hyunhye1ORCID, Park Junhyung1ORCID, Chung Hoyong1ORCID
Affiliation:
1. ANDI Center, 3BIGS Co., Ltd., Hwaseong 18469, Republic of Korea
Abstract
Atopic dermatitis (AD) is a relapsing skin disease with persistent inflammation as a causal factor for symptoms and disease progression. Current therapies provide only temporary relief and require long-term usage accompanied by side effects due to persistent relapses. A short peptide, TPS240, has been tested for its potential to subside AD. In this study, we confirmed the anti-atopic effect of TPS240 in vivo and in vitro using a DNCB-induced AD mouse model and TNF-α/IFN-γ-stimulated HaCaT cells. In the AD mouse model, topical treatment with TPS240 diminished AD-like skin lesions and symptoms such as epidermal thickening and mast cell infiltration induced by DNCB, similar to the existing treatment, dexamethasone (Dex). Furthermore, skin atrophy, weight loss, and abnormal organ weight changes observed in the Dex-treated group were not detected in the TPS240-treated group. In TNF-α/IFN-γ-stimulated HaCaT cells, TPS240 reduced the expression of the inflammatory chemokines CCL17 and CCL22 and the pruritic cytokines TSLP and IL-31 by inhibiting NF-κB and STAT3 activation. These results suggest that TPS240 has an anti-atopic effect through immunomodulation of AD-specific cytokines and chemokines and can be used as a candidate drug for the prevention and treatment of AD that can solve the safety problems of existing treatments.
Funder
3BIGS Research Fund
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference38 articles.
1. Gilaberte, Y., Perez-Gilaberte, J.B., Poblador-Plou, B., Bliek-Bueno, K., Gimeno-Miguel, A., and Prados-Torres, A. (2020). Prevalence and Comorbidity of Atopic Dermatitis in Children: A Large-Scale Population Study Based on Real-World Data. J. Clin. Med., 9. 2. Atopic dermatitis;Langan;Lancet,2020 3. Management of atopic dermatitis: A narrative review;Goh;Med. J. Aust.,2022 4. Atopic Dermatitis in Children and Adults-Diagnosis and Treatment;Wollenberg;Dtsch. Arztebl. Int.,2023 5. Chiricozzi, A., Maurelli, M., Calabrese, L., Peris, K., and Girolomoni, G. (2023). Overview of Atopic Dermatitis in Different Ethnic Groups. J. Clin. Med., 12.
|
|