Does Therapeutic Exercise Support Improvement in Cognitive Function and Instrumental Activities of Daily Living in Patients with Mild Alzheimer’s Disease? A Randomized Controlled Trial
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Published:2023-07-22
Issue:7
Volume:13
Page:1112
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ISSN:2076-3425
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Container-title:Brain Sciences
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language:en
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Short-container-title:Brain Sciences
Author:
Papatsimpas Vasileios123ORCID, Vrouva Sotiria124ORCID, Papathanasiou George12, Papadopoulou Marianna12, Bouzineki Christina5, Kanellopoulou Sophia5, Moutafi Dimitra6, Bakalidou Daphne12
Affiliation:
1. Physiotherapy Department, School of Health and Care Sciences, University of West Attica (UNIWA), 12243 Athens, Greece 2. Laboratory of Neuromuscular and Cardiovascular Study of Motion (LANECASM), School of Health and Care Sciences, University of West Attica (UNIWA), 12243 Athens, Greece 3. Department of Physical Therapy, General Hospital of Athens G. GENNIMATAS, 11527 Athens, Greece 4. Department of Physical Therapy, 401 Army General Hospital of Athens, 11525 Athens, Greece 5. Alzheimer Athens Association, 11636 Athens, Greece 6. Pathological Department, General Hospital Konstantopouleio, 14233 Nea Ionia, Greece
Abstract
This randomized controlled trial aims to investigate the effect of 12 weeks of therapeutic exercise on cognitive function and daily activities in patients with mild Alzheimer’s disease (AD). A total of 171 patients with mild AD from the Amarousion Day Care Center of the Alzheimer Society of Athens and the Athens General Hospital “G. Gennimatas” were randomly divided into three groups. Group A (aerobic and resistance exercise, n = 57), group B (resistance exercise, n = 57), and group C (control group, n = 57). Group A followed a weekly program consisting of 5 days with 30 min walking and 3 days with resistance exercises for about 45 min. Group B followed only a resistance exercise program, the same as group A. Group C did not participate in any exercise program. After the intervention, cognitive function was assessed with the Cognitive Examination-Revised (ACE-R), Trail Making Test A-B (TMT A-B), and Digit Span Test Forward and Backward (DST F-B) and daily activities with the instrumental activities of daily living scale (IADLs). A significant intervention effect was observed for all outcome measures (global cognitive function and instrumental activities of daily living). ANCOVA Bonferroni corrected post hoc tests revealed that the aerobic and resistance group improved compared to the control group on all measurement scales. The resistance group also showed an improvement compared to the control group. No significant effects were found between the aerobic and resistance group and the resistance group in any of the outcome measures.
Funder
Special Account for Research Grants of the University of West Attica
Subject
General Neuroscience
Reference78 articles.
1. Alzheimer’s Association (2021). 2021 Alzheimer’s disease facts and figures. Alzheimer’s Dement. J. Alzheimer’s Assoc., 17, 327–406. 2. Goldberg, S.E., van der Wardt, V., Brand, A., Burgon, C., Bajwa, R., Hoare, Z., Logan, P.L., and Harwood, R.H. (2019). Promoting activity, Independence and stability in early dementia (PrAISED): A, multisite, randomised controlled, feasibility trial. BMC Geriatr., 19. 3. Dementia: Assessment, management and support: Summary of updated NICE guidance;Pink;BMJ,2018 4. Wang, S., Liu, H.Y., Cheng, Y.C., and Su, C.H. (2021). Exercise Dosage in Reducing the Risk of Dementia Development: Mode, Duration, and Intensity-A Narrative Review. Int. J. Environ. Res. Public Health, 18. 5. Ginis, K.A., Heisz, J., Spence, J.C., Clark, I.B., Antflick, J., Ardern, C.I., Costas-Bradstreet, C., Duggan, M., Hicks, A.L., and Latimer-Cheung, A.E. (2017). Formulation of evidence-based messages to promote the use of physical activity to prevent and manage Alzheimer’s disease. BMC Public Health, 17.
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