Relation of MRI-Visible Perivascular Spaces and Other MRI Markers of Cerebral Small Vessel Disease

Author:

Rodriguez Lara Frances1ORCID,Toro Arturo Ruben1,Pinheiro Adlin23,Demissie Serkalem23,Ekenze Oluchi34ORCID,Martinez Oliver5,Parva Pedram67,Charidimou Andreas8,Ghosh Saptaparni38,DeCarli Charles5,Seshadri Sudha389,Habes Mohamad9,Maillard Pauline5,Romero Jose Rafael38

Affiliation:

1. Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA

2. Department of Biostatistics, School of Public Health, Boston University, Boston, MA 02118, USA

3. Framingham Heart Study, National Heart Lung and Blood Institute, Framingham, MA 01702, USA

4. Graduate Medical Sciences, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA

5. Department of Neurology, University of California Davis, Davis, CA 95817, USA

6. Department of Radiology, Veterans Affairs Boston Healthcare System, Boston, MA 02118, USA

7. Department of Radiology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA

8. Department of Neurology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02118, USA

9. The Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX 78229, USA

Abstract

Perivascular spaces (PVS) visible on brain MRI signal cerebral small vessel disease (CSVD). The coexistence of PVS with other CSVD manifestations likely increases the risk of adverse neurological outcomes. We related PVS to other CSVD manifestations and brain volumes that are markers of vascular brain injury and neurodegeneration. Framingham Heart Study (FHS) participants with CSVD ratings on brain MRI were included. PVS were rated in the basal ganglia (BG) and centrum semiovale (CSO) into grades I–IV and a category reflecting high burden in single or mixed CSO-BG regions. We related PVS to covert brain infarcts (CBI), white matter hyperintensities (WMH), cerebral microbleeds (CMB), total brain, hippocampal, and cortical gray matter volumes using adjusted multivariable regression analyses. In 2454 participants (mean age 54 ± 12 years), we observed that higher PVS burden in both BG and CSO was related to CMB in lobar and deep brain regions and increased WMH. Greater CSO PVS burden was associated with decreased total cortical gray volumes. PVS are associated with ischemic markers of CSVD and neurodegeneration markers. Further studies should elucidate the causality between PVS and other CSVD manifestations.

Funder

Framingham Heart Study’s National Heart, Lung, and Blood Institute contract

National Institute of Neurological Disorders and Stroke

National Institute on Aging

NIH grant

Publisher

MDPI AG

Subject

General Neuroscience

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