Another Use for a Proven Drug: Experimental Evidence for the Potential of Artemisinin and Its Derivatives to Treat Alzheimer’s Disease

Author:

Kiss Eva12,Kins Stefan3,Gorgas Karin1,Venczel Szakács Kinga Hajnal2,Kirsch Joachim1,Kuhse Jochen1

Affiliation:

1. Institute of Anatomy and Cell Biology, University of Heidelberg, 69120 Heidelberg, Germany

2. Department of Cellular and Molecular Biology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mures, 540142 Târgu Mures, Romania

3. Department of Human Biology and Human Genetics, University of Kaiserslautern, 69120 Kaiserslautern, Germany

Abstract

Plant-derived multitarget compounds may represent a promising therapeutic strategy for multifactorial diseases, such as Alzheimer’s disease (AD). Artemisinin and its derivatives were indicated to beneficially modulate various aspects of AD pathology in different AD animal models through the regulation of a wide range of different cellular processes, such as energy homeostasis, apoptosis, proliferation and inflammatory pathways. In this review, we aimed to provide an up-to-date overview of the experimental evidence documenting the neuroprotective activities of artemi-sinins to underscore the potential of these already-approved drugs for treating AD also in humans and propose their consideration for carefully designed clinical trials. In particular, the benefits to the main pathological hallmarks and events in the pathological cascade throughout AD development in different animal models of AD are summarized. Moreover, dose- and context-dependent effects of artemisinins are noted.

Funder

Romanian Ministry of Research and Innovation

Publisher

MDPI AG

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