Sex-Related Disparities in the Resting State Functional Connectivity of the Locus Coeruelus and Salience Network in Preclinical Alzheimer’s Disease

Author:

Um Yoo Hyun1ORCID,Wang Sheng-Min2,Kang Dong Woo3ORCID,Kim Sunghwan2ORCID,Lee Chang Uk3,Kim Donghyeon4,Choe Yeong Sim4ORCID,Kim Regina E. Y.4ORCID,Lee Soyoung56,Lim Hyun Kook2ORCID

Affiliation:

1. Department of Psychiatry, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea

2. Department of Psychiatry, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea

3. Department of Psychiatry, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea

4. Research Institute, Neurophet Inc., Seoul 08380, Republic of Korea

5. Department of Psychiatry, Brigham and Women’s Hospital, Boston, MA 02115, USA

6. Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA

Abstract

Recent studies have demonstrated the pivotal role of locus coeruleus (LC) and salience network (SN) resting state functional connectivity (rsFC) changes in the early stage of Alzheimer’s disease (AD). Moreover, sex has been a crucial point of discussion in understanding AD pathology. We aimed to demonstrate the sex-related disparities in the functional connectivity (FC) of the SN and LC in preclinical AD. A total of 89 cognitively normal patients with evidence of amyloid beta (Aβ) accumulation ([18F] flutemetamol +) were recruited in the study. A seed-to-voxel analysis was conducted to measure the LC and SN rsFC differences between sexes. In addition, sex by Aβ interactive effects on FC values were analyzed with a general linear model. There were statistically significant sex by regional standardized uptake value ratio (SUVR) interactions in the LC FC with the parietal, frontal, and occipital cortices. Moreover, there was a significant sex by global SUVR interaction in the SN FC with the temporal cortex. The findings suggest that there are differential patterns of LC FC and SN FC in males and females with preclinical AD, which interact with regional Aβ deposition.

Funder

Korea Health Technology R & D Project through the Korea Health Industry Development Institute (KHIDI) and Korea Dementia Research Center

Ministry of Health & Welfare and Ministry of Science and ICT

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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