Iron, Ferroptosis, and Head and Neck Cancer

Author:

Teng Yong12ORCID,Gao Lixia3,Mäkitie Antti A.4,Florek Ewa5ORCID,Czarnywojtek Agata67,Saba Nabil F.1ORCID,Ferlito Alfio8ORCID

Affiliation:

1. Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA

2. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA

3. College of Pharmaceutical Sciences and Chinese Medicine, Southwest University, Chongqing 400715, China

4. Department of Otorhinolaryngology-Head and Neck Surgery, Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, FI-00014 Helsinki, Finland

5. Laboratory of Environmental Research, Department of Toxicology, Poznan University of Medical Sciences, 60-631 Poznan, Poland

6. Department of Pharmacology, Poznan University of Medical Sciences, 60-806 Poznan, Poland

7. Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznan, Poland

8. Coordinator of the International Head and Neck Scientific Group, 35125 Padua, Italy

Abstract

Ferroptosis is an iron-dependent regulatory form of cell death characterized by the accumulation of intracellular reactive oxygen species and lipid peroxidation. It plays a critical role not only in promoting drug resistance in tumors, but also in shaping therapeutic approaches for various malignancies. This review aims to elucidate the relationship between ferroptosis and head and neck cancer treatment by discussing its conceptual framework, mechanism of action, functional aspects, and implications for tumor therapy. In addition, this review consolidates strategies aimed at improving the efficacy of head and neck cancer treatment through modulation of ferroptosis, herein serving as a valuable reference for advancing the treatment landscape for this patient population.

Funder

NIH/NIDCR

Winship Cancer Institute of Emory University

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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