Non-Steroidal Estrogens Inhibit Influenza Virus by Interacting with Hemagglutinin and Preventing Viral Fusion-Reference-Cited by-同舟云学术

Non-Steroidal Estrogens Inhibit Influenza Virus by Interacting with Hemagglutinin and Preventing Viral Fusion

Published:2023-10-19 Issue:20 Volume:24 Page:15382
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Franzi Elisa¹,Mathez Gregory¹^ORCID,Dinant Soraya²^ORCID,Deloizy Charlotte²,Kaiser Laurent³⁴,Tapparel Caroline⁵^ORCID,Le Goffic Ronan²,Cagno Valeria¹^ORCID

Affiliation:

1. Institute of Microbiology, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland

2. INRAE, UVSQ, UMR892 VIM, Université Paris-Saclay, 78350 Jouy-en-Josas, France

3. Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, University Hospitals of Geneva, University of Geneva, 1206 Geneva, Switzerland

4. Center for Emerging Viruses, Geneva University Hospitals, 1205 Geneva, Switzerland

5. Department of Microbiology and Molecular Medicine, University of Geneva, 1206 Geneva, Switzerland

Abstract

Influenza virus is one of the main causes of respiratory infections worldwide. Despite the availability of seasonal vaccines and antivirals, influenza virus infections cause an important health and economic burden. Therefore, the need to identify alternative antiviral strategies persists. In this study, we identified non-steroidal estrogens as potent inhibitors of influenza virus due to their interaction with the hemagglutinin protein, preventing viral entry. This activity is maintained in vitro, ex vivo, and in vivo. Therefore, we found a new domain to target on the hemagglutinin and a class of compounds that could be further optimized for influenza treatment.

Funder

Swiss National Science Foundation

University Hospital of Geneva PRD

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/20/15382/pdf

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