Study of the Embryonic Toxicity of TiO2 and ZrO2 Nanoparticles-Reference-Cited by-同舟云学术

Study of the Embryonic Toxicity of TiO2 and ZrO2 Nanoparticles

Published:2023-01-31 Issue:2 Volume:14 Page:363
ISSN:2072-666X
Container-title:Micromachines
language:en
Short-container-title:Micromachines

Author:

Lyashenko Elena Nikolaevna¹,Uzbekova Leyla Djavadovna²,Polovinkina Valeri Vladimirovna¹,Dorofeeva Anastasia Konstantinovna²,Ibragimov Said-Umar Sithalil-ugli¹,Tatamov Arslan Ayavovich³,Avkaeva Albina Gamdullaevna³,Mikhailova Anastasia Alekseevna⁴,Tuaeva Inga Shamilevna⁵,Esiev Ruslan Kazbekovich⁶,Mezentsev Sergei Dmitrievich⁷,Gubanova Marina Alexandrovna⁸,Bondarenko Natalya Grigorevna⁹,Maslova Alina Yurievna⁴¹⁰

Affiliation:

1. Department of Obstetrics and Gynecology, Faculty of Pediatrics, S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, 295007 Simferopol, Russia

2. Faculty of Pediatrics, Rostov State Medical University, 344009 Rostov-on-Don, Russia

3. Faculty of Medicine, Dagestan State Medical University, 367029 Makhachkala, Russia

4. Faculty of Medicine, Stavropol State Medical University, 355017 Stavropol, Russia

5. Department of Hygiene, Faculty of Medicine and Prevention, North Ossetian State Medical Academy, 362019 Vladikavkaz, Russia

6. Department of Dentistry, North Ossetian State Medical Academy, 362019 Vladikavkaz, Russia

7. Department of the National Research, Moscow State University of Civil Engineering, 125009 Moscow, Russia

8. Armavir State Pedagogical University, 352901 Armavir, Russia

9. Department of Philosophy of History of Law, Pyatigorsk Branch of North Caucasus Federal University, 357502 Pyatigorsk, Russia

10. SocMedica, 121205 Moscow, Russia

Abstract

Currently, the widespread use of TiO2 and ZrO2 nanoparticles (NPs) in various industries poses a risk in terms of their potential toxicity. A number of experimental studies provide evidence of the toxic effect of TiO2 and ZrO2 NPs on biological objects. In order to supplement the level of knowledge and assess the risks of toxicity and danger of TiO2 and ZrO2 NPs, we decided to conduct a comprehensive experiment to study the embryonic toxicity of TiO2 and ZrO2 NPs in pregnant rats. For the experiment, mongrel white rats during pregnancy received aqueous dispersions of powders of TiO2 and ZrO2 NPs at a dose of 100 mg/kg/day. To characterize the effect of TiO2 and ZrO2 NPs on females and the postnatal ontogenesis of offspring, a complex of physiological and biochemical research methods was used. The results of the experiment showed that TiO2 NPs as ZrO2 NPs (100 mg/kg per os) cause few shifts of similar orientation in the maternal body. Neither TiO2 NPs nor ZrO2 NPs have an embryonic and teratogenic effect on the offspring in utero, but both modify its postnatal development.

Publisher

MDPI AG

Subject

Electrical and Electronic Engineering,Mechanical Engineering,Control and Systems Engineering

Link

https://www.mdpi.com/2072-666X/14/2/363/pdf

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