Real-World Retrospective Study into the Effects of Oral Semaglutide (As a Switchover or Add-On Therapy) in Type 2 Diabetes

Author:

Candido Riccardo12,Gaiotti Sara1,Giudici Fabiola1ORCID,Toffoli Barbara1ORCID,De Luca Federica1,Velardi Valerio1ORCID,Petrucco Alessandra2,Gottardi Chiara2,Manca Elena2,Buda Iris2,Fabris Bruno13,Bernardi Stella13ORCID

Affiliation:

1. Department of Medical Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy

2. SC Patologie Diabetiche, ASUGI (Azienda Sanitaria Universitaria Giuliano Isontina), 34128 Trieste, Italy

3. SS Endocrinologia Medicina Clinica, ASUGI (Azienda Sanitaria Universitaria Giuliano Isontina), 34128 Trieste, Italy

Abstract

(1) Background: Oral semaglutide represents the first oral GLP-1 RA approved for the treatment of type 2 diabetes mellitus (T2DM). This real-world retrospective study aimed at evaluating its effectiveness and tolerability in the treatment of patients with T2DM when patients switched from a glucose-lowering agent to it and when it was added to the usual therapy. (2) Methods: Adult patients with T2DM taking oral semaglutide and followed in the ASUGI Diabetes Center were identified with the use of electronic medical records between October 2022 and May 2023. (3) Results: A total of 129 patients were recruited. The median follow-up was 6 months. Be it as a switchover or as an add-on therapy, oral semaglutide significantly reduced HbA1c and BMI. Switching from DPPIV inhibitors to oral semaglutide was associated with a significant reduction in HbA1c and BMI, switching from SGLT2 inhibitors was associated with a significant reduction in HbA1c, and switching from sulphonylureas was associated with a significant reduction in BMI. The median HbA1c change was associated with baseline HbA1c. SBP significantly decreased in the add-on group. Oral semaglutide was well tolerated. (4) Conclusions: This study shows that in the real-world setting, oral semaglutide is effective and safe as a switchover or as an add-on therapy for the treatment of T2DM.

Publisher

MDPI AG

Subject

General Medicine

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