Assessment of Microvascular Disease in Heart and Brain by MRI: Application in Heart Failure with Preserved Ejection Fraction and Cerebral Small Vessel Disease

Author:

Bennett Jonathan12ORCID,van Dinther Maud34ORCID,Voorter Paulien56ORCID,Backes Walter456ORCID,Barnes Josephine7,Barkhof Frederick8910,Captur Gabriella11112,Hughes Alun D.111ORCID,Sudre Carole7101113,Treibel Thomas A.12

Affiliation:

1. Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK

2. Department of Cardiology, Barts Heart Centre, London EC1A 7BE, UK

3. Department of Neurology, Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands

4. School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6211 LX Maastricht, The Netherlands

5. Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands

6. School for Mental Health & Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands

7. Dementia Research Centre, UCL Queens Square Institute of Neurology, University College London, London WC1E 6BT, UK

8. Department of Radiology & Nuclear Medicine, Amsterdam UMC, Vrije University, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands

9. Queen Square Institute of Neurology, University College London, London WC1E 6BT, UK

10. Centre for Medical Image Computing, University College London, London WC1E 6BT, UK

11. Medical Research Council Unit for Lifelong Health and Ageing, Department of Population Science and Experimental Medicine, University College London, London WC1E 6BT, UK

12. Centre for Inherited Heart Muscle Conditions, Cardiology Department, The Royal Free Hospital, London NW3 2QG, UK

13. School of Biomedical Engineering and Imaging Sciences, King’s College London, London WC2R 2LS, UK

Abstract

The objective of this review is to investigate the commonalities of microvascular (small vessel) disease in heart failure with preserved ejection fraction (HFpEF) and cerebral small vessel disease (CSVD). Furthermore, the review aims to evaluate the current magnetic resonance imaging (MRI) diagnostic techniques for both conditions. By comparing the two conditions, this review seeks to identify potential opportunities to improve the understanding of both HFpEF and CSVD.

Funder

European Commission

UK Medical Research Council

British Heart Foundation

National Institute for Health Research University College London Hospitals Biomedical Research Centre

Publisher

MDPI AG

Subject

General Medicine

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