Affiliation:
1. Department of Pharmacology, Joint Laboratory of Guangdong–Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China
Abstract
The ORAI proteins serve as crucial pore-forming subunits of calcium-release-activated calcium (CRAC) channels, pivotal in regulating downstream calcium-related signaling pathways. Dysregulated calcium homeostasis arising from mutations and post-translational modifications in ORAI can lead to immune disorders, myopathy, cardiovascular diseases, and even cancers. Small molecules targeting ORAI present an approach for calcium signaling modulation. Moreover, emerging techniques like optogenetics and optochemistry aim to offer more precise regulation of ORAI. This review focuses on the role of ORAI in cancers, providing a concise overview of their significance in the initiation and progression of cancers. Additionally, it highlights state-of-the-art techniques for ORAI channel modulation, including advanced optical tools, potent pharmacological inhibitors, and antibodies. These novel strategies offer promising avenues for the functional regulation of ORAI in research and may inspire innovative approaches to cancer therapy targeting ORAI.
Funder
National Natural Science Foundation of China
Shenzhen Medical Research Fund
Reference144 articles.
1. Gao, X.H., Di, X.H., Li, J.J., Kang, Y.T., Xie, W.J., Sun, L.J., and Zhang, J.B. (2023). Extracellular Calcium-Induced Calcium Transient Regulating the Proliferation of Osteoblasts through Glycolysis Metabolism Pathways. Int. J. Mol. Sci., 24.
2. Hammad, A.S., and Machaca, K. (2021). Store Operated Calcium Entry in Cell Migration and Cancer Metastasis. Cells, 10.
3. PDGF-stimulated calcium influx changes during in vitro cell transformation;Estacion;Cell. Signal.,1997
4. Calcium Homeostasis in the Control of Mitophagy;Perrone;Antioxid. Redox Sign.,2023
5. A Model for Receptor-Regulated Calcium Entry;Putney;Cell Calcium,1986
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. S‐acylation of Ca2+ transport proteins in cancer;Chronic Diseases and Translational Medicine;2024-08-14