Morphology, Cytotoxicity, and Antimicrobial Activity of Electrospun Polycaprolactone Biomembranes with Gentamicin and Nano-Hydroxyapatite-Reference-Cited by-同舟云学术

Morphology, Cytotoxicity, and Antimicrobial Activity of Electrospun Polycaprolactone Biomembranes with Gentamicin and Nano-Hydroxyapatite

Published:2023-12-28 Issue:1 Volume:14 Page:10
ISSN:2077-0375
Container-title:Membranes
language:en
Short-container-title:Membranes

Author:

Mirica Ioana-Codruta¹,Furtos Gabriel²^ORCID,Moldovan Marioara²^ORCID,Prodan Doina²^ORCID,Petean Ioan³^ORCID,Campian Radu-Septimiu¹,Pall Emoke⁴^ORCID,Lucaciu Ondine¹^ORCID

Affiliation:

1. Department of Oral Health, Iuliu Hatieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania

2. Department of Dental Materials, Raluca Ripan, Institute of Research in Chemistry, Babes-Bolyai University, 400294 Cluj-Napoca, Romania

3. Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University, 400294 Cluj-Napoca, Romania

4. Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania

Abstract

The aim of this research is to develop new nanocomposite membranes (NMs) for guided bone regeneration from polycaprolactone (PCL), with different concentrations of gentamicin sulfate (GEN) and nano-hydroxyapatite (nHAP) through electrospinning. The obtained NMs were characterized for structure through SEM and AFM, which revealed the influence of GEN and nHAP on the fiber diameter. The addition of GEN lowered the fiber diameter, and the addition of nHAP increased the diameter of the fibers. The NMs demonstrated antibacterial properties against P. aeruginosa, S. aureus, B. cereus, and E. coli depending on the drug concentration, while being negligibly affected by the nHAP content. NM cytotoxicity assessment, performed once using the MTT assay, revealed no cytotoxicity. The developed NMs could be a promising alternative for guided bone regeneration.

Funder

project PDI-PFE-CDI 2021

Ministry of Research, Innovation and Digitization

Publisher

MDPI AG

Subject

Filtration and Separation,Chemical Engineering (miscellaneous),Process Chemistry and Technology

Link

https://www.mdpi.com/2077-0375/14/1/10/pdf

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