A Green Synthesis of 3-Selanyl-Isoflavones via Lipase Mediated Selenylation/Cyclization of Enaminones
-
Published:2024-06-28
Issue:7
Volume:14
Page:413
-
ISSN:2073-4344
-
Container-title:Catalysts
-
language:en
-
Short-container-title:Catalysts
Author:
Kan Wenbo1, Piao Yuming1, Song Wenning1, Chen Xiaoxuan1, Wang Chunyu2, Wang Zhi1ORCID, Wang Lei1
Affiliation:
1. Key Laboratory of Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130023, China 2. State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130023, China
Abstract
Herein, a green biocatalytic approach using lipase as a catalyst has been developed for the synthesis of 3-selanyl-isoflavones through the selenylation/cyclization of 2-hydroxyphenyl enaminones and diphenyl di-selenide under mild conditions. The environmentally friendly method reached high yields of 87–95% in a short time at 30 °C, with 17 examples of 3-selanyl-isoflavones successfully prepared. Furthermore, we have investigated the possible mechanisms underlying this reaction.
Funder
Science and Technology Development Program of Jilin Province
Reference40 articles.
1. Chen, Y., Cheng, F.-B., Wu, X.-R., Zhu, W., Liao, J.-W., Jiang, Y., Zhang, C., Niu, W.-Y., Yu, Y., and Duan, H.-Q. (2020). Flavonoid derivatives synthesis and anti-diabetic activities. Bioorg. Chem., 95. 2. Promiscuous enzyme-catalyzed cascade reaction: Synthesis of xanthone derivatives;Fu;Bioorg. Chem.,2018 3. Li, H., Lyv, Y., Zhou, S., Yu, S., and Zhou, J. (2022). Microbial cell factories for the production of flavonoids–barriers and opportunities. Bioresour. Technol., 360. 4. Uddin, M.S., Kabir, M.T., Niaz, K., Jeandet, P., Clément, C., Mathew, B., Rauf, A., Rengasamy, K.R.R., Sobarzo-Sánchez, E., and Ashraf, G.M. (2020). Molecular Insight into the Therapeutic Promise of Flavonoids against Alzheimer’s Disease. Molecules, 25. 5. Ullah, A., Munir, S., Badshah, S.L., Khan, N., Ghani, L., Poulson, B.G., Emwas, A.-H., and Jaremko, M. (2020). Important Flavonoids and Their Role as a Therapeutic Agent. Molecules, 25.
|
|