Genome-Wide Association Analysis Identifies Genomic Regions and Candidate Genes for Growth and Fatness Traits in Diannan Small-Ear (DSE) Pigs
Author:
Liu Mei1ORCID, Lan Qun1, Yang Long1, Deng Qiuchun1, Wei Taiyun2, Zhao Heng2, Peng Peiya1, Lin Xiaoding1, Chen Yuhan1, Ma Haiming13ORCID, Wei Hongjiang2ORCID, Yin Yulong134
Affiliation:
1. College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China 2. Yunnan Province Key Laboratory for Porcine Gene Editing and Xenotransplantation, Yunnan Agricultural University, Kunming 650201, China 3. Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China 4. Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China
Abstract
In the livestock industry, the growth and fatness traits are directly related to production efficiency and economic profits. As for Diannan small-ear (DSE) pigs, a unique indigenous breed, the genetic architecture of growth and fatness traits is still elusive. The aim of this study was to search the genetic loci and candidate genes associated with phenotypic traits in DSE pigs using GWAS based on the Geneseek Porcine 50K SNP Chip data. A total of 22,146 single nucleotide polymorphisms (SNPs) were detected in 265 DSE pigs and used for Genome-wide association studies (GWAS) analysis. Seven SNPs were found to be associated with back height, chest circumference, cannon bone circumference, and backfat thickness at the suggestive significance level. Based on gene annotation results, these seven SNPs were, respectively, mapped to the following candidate genes, VIPR2, SLC10A2, NUCKS1, MCT1, CHCHD3, SMOX, and GPR1, which are mainly involved with adipocyte differentiation, lipid metabolism, skeletal muscle development, and average daily weight gain. Our work offers novel insights into the genetic architecture of economically important traits in swine and may play an important role in breeding using molecular markers in the DSE breed.
Funder
Laboratory of Lingnan Modern Agriculture Project National Natural Science Foundation of China Natural Science Foundation of Hunan Province Breeding and Promotion of Lancang black pig Key Science and Technology Project of Yunnan Province
Subject
General Veterinary,Animal Science and Zoology
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