Affiliation:
1. Department of Pediatric Infectious Diseases, Medical University of Bialystok, Waszyngtona 17, 15-274 Bialystok, Poland
Abstract
Adipokines are protein hormones secreted by adipose tissue in response to disruptions in physiological homeostasis within the body’s systems. The regulatory functions of adipokines within the central nervous system (CNS) are multifaceted and intricate, and they have been identified in a number of pathologies. Therefore, specific adipokines have the potential to be used as biomarkers for screening purposes in neurological dysfunctions. The systematic review presented herein focuses on the analysis of the functions of various adipokines in the pathogenesis of CNS diseases. Thirteen proteins were selected for analysis through scientific databases. It was found that these proteins can be identified within the cerebrospinal fluid either by their ability to modify their molecular complex and cross the blood–brain barrier or by being endogenously produced within the CNS itself. As a result, this can correlate with their measurability during pathological processes, including Alzheimer’s disease, amyotrophic lateral sclerosis, multiple sclerosis, depression, or brain tumors.
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference151 articles.
1. Determination of Cerebrospinal Fluid Cystatin C on Architect Ci8200;Ndjole;J. Immunol. Methods,2010
2. Can Cystatin C in Cerebrospinal Fluid Be a Biomarker for Amyotrophic Lateral Sclerosis? A Lesson from Previous Studies;Sako;Neurol. Clin. Neurosci.,2014
3. Lifetime Risk of CKD: What Does It Really Mean?;Delanaye;Clin. J. Am. Soc. Nephrol.,2015
4. Geary, D.F., and Schaefer, F. (2008). Comprehensive Pediatric Nephrology, Elsevier.
5. Successful Vancomycin Dose Adjustment in a Sepsis Patient with Bacterial Meningitis Using Cystatin C;Chuma;Acta Med. Okayama,2020