Abstract
Sjogren’s syndrome (SS) is a chronic autoimmune disease characterized by the infiltration of exocrine glands including salivary and lachrymal glands responsible for the classical dry eyes and mouth symptoms (sicca syndrome). The spectrum of disease manifestations stretches beyond the classical sicca syndrome with systemic manifestations including arthritis, interstitial lung involvement, and neurological involvement. The pathophysiology underlying SS is not well deciphered, but several converging lines of evidence have supported the conjuncture of different factors interplaying together to foster the initiation and perpetuation of the disease. The innate and adaptive immune system play a cardinal role in this process. In this review, we discuss the inherent parts played by both the innate and adaptive immune system in the pathogenesis of SS.
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference164 articles.
1. Pathogenesis of Sjogren’s syndrome;Fox;Rheum. Dis. Clin. N. Am.,1992
2. Approaches to the treatment of Sjogren’s syndrome;Fox;J. Rheumatol. Suppl.,2000
3. OPIOID REGULATION OF NOCICEPTIVE AND NEUROPATHIC PAIN
4. Sex hormones and Sjogren’s syndrome;Sullivan;J. Rheumatol. Suppl.,1997
5. Unraveling the Pathophysiology of Sjogren Syndrome-Associated Dry Eye Disease
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