miRNA-Based Technologies in Cancer Therapy-Reference-Cited by-同舟云学术

miRNA-Based Technologies in Cancer Therapy

Published:2023-11-09 Issue:11 Volume:13 Page:1586
ISSN:2075-4426
Container-title:Journal of Personalized Medicine
language:en
Short-container-title:JPM

Author:

Pagoni Maria¹^ORCID,Cava Claudia²^ORCID,Sideris Diamantis C.³,Avgeris Margaritis⁴^ORCID,Zoumpourlis Vassilios⁵,Michalopoulos Ioannis⁶^ORCID,Drakoulis Nikolaos¹^ORCID

Affiliation:

1. Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15701 Athens, Greece

2. Department of Science, Technology and Society, University School for Advanced Studies IUSS Pavia, 27100 Pavia, Italy

3. Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, 15701 Athens, Greece

4. Laboratory of Clinical Biochemistry—Molecular Diagnostics, Second Department of Pediatrics, School of Medicine, “P. & A. Kyriakou” Children’s Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece

5. Biomedical Applications Unit, Institute of Chemical Biology, National Hellenic Research Foundation (NHRF), 11635 Athens, Greece

6. Centre of Systems Biology, Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece

Abstract

The discovery of therapeutic miRNAs is one of the most exciting challenges for pharmaceutical companies. Since the first miRNA was discovered in 1993, our knowledge of miRNA biology has grown considerably. Many studies have demonstrated that miRNA expression is dysregulated in many diseases, making them appealing tools for novel therapeutic approaches. This review aims to discuss miRNA biogenesis and function, as well as highlight strategies for delivering miRNA agents, presenting viral, non-viral, and exosomic delivery as therapeutic approaches for different cancer types. We also consider the therapeutic role of microRNA-mediated drug repurposing in cancer therapy.

Publisher

MDPI AG

Subject

Medicine (miscellaneous)

Link

https://www.mdpi.com/2075-4426/13/11/1586/pdf

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