Ex Vivo-Generated Tolerogenic Dendritic Cells: Hope for a Definitive Therapy of Autoimmune Diseases-Reference-Cited by-同舟云学术

Ex Vivo-Generated Tolerogenic Dendritic Cells: Hope for a Definitive Therapy of Autoimmune Diseases

Published:2024-04-28 Issue:5 Volume:46 Page:4035-4048
ISSN:1467-3045
Container-title:Current Issues in Molecular Biology
language:en
Short-container-title:CIMB

Author:

Jonny ¹²³^ORCID,Sitepu Enda Cindylosa¹,Nidom Chairul A.⁴⁵^ORCID,Wirjopranoto Soetojo⁶,Sudiana I. Ketut⁶,Ansori Arif N. M.⁴,Putranto Terawan Agus¹

Affiliation:

1. Indonesia Army Cellcure Center, Gatot Soebroto Central Army Hospital, Jakarta 10410, Indonesia

2. Faculty of Medicine, University Prima Indonesia, Medan 20118, Indonesia

3. Faculty of Military Medicine, Indonesia Defense University, Jakarta 16810, Indonesia

4. Professor Nidom Foundation, Surabaya 60236, Indonesia

5. Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya 60115, Indonesia

6. Faculty of Medicine, Universitas Airlangga, Surabaya 60115, Indonesia

Abstract

Current therapies for autoimmune diseases are immunosuppressant agents, which have many debilitating side effects. However, dendritic cells (DCs) can induce antigen-specific tolerance. Tolerance restoration mediated by ex vivo-generated DCs can be a therapeutic approach. Therefore, in this review, we summarize the conceptual framework for developing ex vivo-generated DC strategies for autoimmune diseases. First, we will discuss the role of DCs in developing immune tolerance as a foundation for developing dendritic cell-based immunotherapy for autoimmune diseases. Then, we also discuss relevant findings from pre-clinical and clinical studies of ex vivo-generated DCs for therapy of autoimmune diseases. Finally, we discuss problems and challenges in dendritic cell therapy in autoimmune diseases. Throughout the article, we discuss autoimmune diseases, emphasizing SLE.

Funder

Indonesia Army Cellcure Center

Publisher

MDPI AG

Link

https://www.mdpi.com/1467-3045/46/5/249/pdf

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