The Association between Childhood Obesity and Cardiovascular Changes in 10 Years Using Special Data Science Analysis

Author:

Cordeiro João Rala1ORCID,Mosca Sara2ORCID,Correia-Costa Ana3ORCID,Ferreira Cátia456ORCID,Pimenta Joana3,Correia-Costa Liane245ORCID,Barros Henrique456,Postolache Octavian1ORCID

Affiliation:

1. Instituto de Telecomunicações, IT-IUL, Iscte—Instituto Universitário de Lisboa, 1649-026 Lisbon, Portugal

2. Pediatric Nephrology Unit, Centro Materno-Infantil do Norte, Centro Hospitalar Universitário de Santo António, 4099-001 Porto, Portugal

3. Division of Paediatric Cardiology, Centro Hospitalar Universitário São João, 4200-319 Porto, Portugal

4. EPIUnit—Instituto de Saúde Pública, Universidade do Porto, Rua das Taipas, n° 135, 4050-600 Porto, Portugal

5. Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR), Universidade do Porto, Rua das Taipas, n° 135, 4050-600 Porto, Portugal

6. Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina, Universidade do Porto, 4200-319 Porto, Portugal

Abstract

The increasing prevalence of overweight and obesity is a worldwide problem, with several well-known consequences that might start to develop early in life during childhood. The present research based on data from children that have been followed since birth in a previously established cohort study (Generation XXI, Porto, Portugal), taking advantage of State-of-the-Art (SoA) data science techniques and methods, including Neural Architecture Search (NAS), explainable Artificial Intelligence (XAI), and Deep Learning (DL), aimed to explore the hidden value of data, namely on electrocardiogram (ECG) records performed during follow-up visits. The combination of these techniques allowed us to clarify subtle cardiovascular changes already present at 10 years of age, which are evident from ECG analysis and probably induced by the presence of obesity. The proposed novel combination of new methodologies and techniques is discussed, as well as their applicability in other health domains.

Funder

Fundação para a Ciência e Tecnologia

Publisher

MDPI AG

Subject

Pediatrics, Perinatology and Child Health

Reference34 articles.

1. Childhood obesity and the associated rise in cardiometabolic complications;Caprio;Nat. Metab.,2020

2. World Health Organization (2018). Taking Action on Childhood Obesity Report, World Health Organization.

3. Obesity: Global epidemiology and pathogenesis;Nat. Rev. Endocrinol.,2019

4. Obesity in children and young people: A crisis in public health;Lobstein;Obes. Rev.,2004

5. Health consequences of obesity;Reilly;Arch. Dis. Child.,2003

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