Multimodality Imaging Assessment of Tetralogy of Fallot: From Diagnosis to Long-Term Follow-Up

Author:

Moscatelli Sara123,Pergola Valeria4ORCID,Motta Raffaella4ORCID,Fortuni Federico56ORCID,Borrelli Nunzia7,Sabatino Jolanda8,Leo Isabella8ORCID,Avesani Martina9,Montanaro Claudia101112ORCID,Surkova Elena13,Mapelli Massimo1415ORCID,Perrone Marco Alfonso1617ORCID,di Salvo Giovanni9ORCID

Affiliation:

1. Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London WC1N 3JH, UK

2. Institute of Cardiovascular Sciences, University College London, London WC1E 6BT, UK

3. Paediatric Cardiology Department, Royal Brompton and Harefield Hospitals, Guy’s and St. Thomas’ NHS Foundation Trust, London SW3 5NP, UK

4. Dipartimento di Scienze Cardio-Toraco-Vascolari e Sanità pubblica, University Hospital of Padua, 35128 Padua, Italy

5. Department of Cardiology, San Giovanni Battista Hospital, 06034 Foligno, Italy

6. Department of Cardiology, Leiden University Medical Center, 2300 Leiden, The Netherlands

7. Adult Congenital Heart Disease Unit, A.O. dei Colli, Monaldi Hospital, 80131 Naples, Italy

8. Experimental and Clinical Medicine Department, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy

9. Division of Paediatric Cardiology, Department of Women and Children’s Health, University Hospital of Padua, 35128 Padua, Italy

10. Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital, Guy’s and St. Thomas’s NHS Foundation Trust, London SW3 5NP, UK

11. CMR Unit, Cardiology Department, Royal Brompton and Harefield Hospitals, Guy’s and St. Thomas’ NHS Foundation Trust, London SW3 5NP, UK

12. National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK

13. Department of Echocardiography, Royal Brompton and Harefield Hospitals, Guy’s and St. Thomas’ NHS Foundation Trust, London SW3 5NP, UK

14. Centro Cardiologico Monzino, IRCCS, 20138 Milan, Italy

15. Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan, 20122 Milan, Italy

16. Clinical Pathways and Epidemiology Unit, Bambino Gesù Children’s Hospital IRCCS, 00165 Rome, Italy

17. Division of Cardiology and Cardio Lab, Department of Clinical Science and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy

Abstract

Tetralogy of Fallot (TOF) is the most common complex congenital heart disease with long-term survivors, demanding serial monitoring of the possible complications that can be encountered from the diagnosis to long-term follow-up. Cardiovascular imaging is key in the diagnosis and serial assessment of TOF patients, guiding patients’ management and providing prognostic information. Thorough knowledge of the pathophysiology and expected sequalae in TOF, as well as the advantages and limitations of different non-invasive imaging modalities that can be used for diagnosis and follow-up, is the key to ensuring optimal management of patients with TOF. The aim of this manuscript is to provide a comprehensive overview of the role of each modality and common protocols used in clinical practice in the assessment of TOF patients.

Publisher

MDPI AG

Subject

Pediatrics, Perinatology and Child Health

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