Diagnostic Utility of Interleukin-6 in Early-Onset Sepsis among Term Newborns: Impact of Maternal Risk Factors and CRP Evaluation

Author:

Schleier Maria1,Lubig Julia1,Kehl Sven2,Hébert Steven1,Woelfle Joachim1ORCID,van der Donk Adriana1,Bär Alisa1,Reutter Heiko13ORCID,Hepp Tobias4,Morhart Patrick1ORCID

Affiliation:

1. Department of Pediatrics and Adolescent Medicine, Division of Neonatology and Pediatric Intensive Care, Friedrich-Alexander-University of Erlangen-Nürnberg, Loschgestraße 15, 91054 Erlangen, Germany

2. Department of Gynecology and Obstetrics Medicine, Division of Obstetrics, Friedrich-Alexander-University of Erlangen-Nürnberg, Universitätsstraße 21/23, 91054 Erlangen, Germany

3. Institute of Human Genetics, Friedrich-Alexander-University of Erlangen-Nürnberg, 91054 Erlangen, Germany

4. Institute for Medical Informatics, Biometry and Epidemiology (IMBE), Friedrich-Alexander-University Erlangen-Nürnberg, Waldstraße 6, 91054 Erlangen, Germany

Abstract

(1) Background: Interleukin-6 (IL-6) levels act as an early infection marker preceding C-reactive protein (CRP) elevation. This study seeks to analyze IL-6 behavior in suspected early-onset sepsis (EOS) cases among term newborns, comparing it to that of CRP and evaluating IL-6’s diagnostic utility. We also aim to assess the impact of maternal risk factors on EOS in term newborns, quantifying their influence for informed decision making. (2) Methods: The retrospective data analysis included 533 term newborns who were admitted to our hospital because of suspected EOS. IL-6, CRP, and the impact of maternal risk factors were analyzed in the context of EOS using binomial test, Chi-squared test, logistic and linear regression. (3) Results: In the cases of EOS, both IL-6 and CRP were elevated. The increase in CRP can be predicted by the initial increase in IL-6 levels. Among the assessed risk factors, intrapartum maternal fever (adjusted odds ratio 18.1; 95% CI (1.7–4.1)) was identified as the only risk factor significantly associated with EOS. (4) Conclusions: Employing IL-6 as an early infection marker enhanced EOS diagnostic precision due to its detectable early rise. However, caution is required, as elevations in IL-6 and CRP levels do not exclusively indicate EOS. Increased CRP levels in healthy newborns with maternal risk factors may be attributed to dynamics of vaginal labor.

Funder

Deutsche Forschungsgemeinschaft

Friedrich–Alexander-Universität Erlangen-Nürnberg

Open Access Publication Funding

Publisher

MDPI AG

Subject

Pediatrics, Perinatology and Child Health

Reference47 articles.

1. AWMF (2023, August 21). Bakterielle Infektionen bei Neugeborenen. Available online: https://register.awmf.org/assets/guidelines/024-008l_S2k_Bakterielle_Infektionen_Neugeborene_2021-03.pdf.

2. Defining neonatal sepsis;Wynn;Curr. Opin. Pediatr.,2016

3. The burden of invasive early-onset neonatal sepsis in the United States, 2005–2008;Weston;Pediatr. Infect. Dis. J.,2011

4. Inflammatory markers in cord blood or maternal serum for early detection of neonatal sepsis-a systemic review and meta-analysis;Su;J. Perinatol.,2014

5. Interleukin-6 as a Biomarker of Early-Onset Neonatal Sepsis;Cortes;Am. J. Perinatol.,2021

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. CD64 and I/T Ratio as a Diagnostic Test on Neonatal Sepsis in Banjarmasin;INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY;2024-02-16

2. Interleukin-6 as a marker of infection generalization in neonatal sepsis;Russian Journal of Anesthesiology and Reanimatology;2024

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3