Micronutrient Deficiency in Children and Adolescents with Obesity—A Narrative Review

Author:

Calcaterra Valeria12ORCID,Verduci Elvira23ORCID,Milanta Chiara2,Agostinelli Marta2,Todisco Carolina Federica2,Bona Federica2,Dolor Jonabel2,La Mendola Alice2,Tosi Martina2ORCID,Zuccotti Gianvincenzo24ORCID

Affiliation:

1. Pediatrics and Adolescentology Unit, Department of Internal Medicine, University of Pavia, 27100 Pavia, Italy

2. Pediatric Department, Buzzi Children’s Hospital, 20154 Milan, Italy

3. Department of Health Sciences, University of Milan, 20142 Milan, Italy

4. Department of Biomedical and Clinical Science, University of Milan, 20157 Milan, Italy

Abstract

Childhood obesity represents a serious public health burden. Despite excessive dietary consumption, children with obesity present high rates of micronutrient deficiencies, such as deficiencies in minerals and specific vitamins; micronutrient deficiencies may have a pathogenic role in obesity-related metabolic comorbidities. In this narrative review, we analyzed the main deficiencies associated with obesity, their clinical consequences, and the evidence about a possible supplementation. Iron; vitamins A, B, C, D, and E; folic acid; zinc; and copper deficiencies represent the most common deficient microelements. The relationship between obesity and multiple micronutrient deficiencies remains unclear, and different mechanisms have been proposed. The medical care plan for pediatric obesity should include food choices with high nutritional content as part of a crucial approach to obesity-related complications. Unfortunately, only a few studies are available regarding the efficacy of oral supplementation or weight loss for treating them; thus, continuous nutritional monitoring is necessary.

Funder

National Recovery and Resilience Plan

European Union-NextGenerationEU

Italian Ministry of University and Research

Publisher

MDPI AG

Subject

Pediatrics, Perinatology and Child Health

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