Affiliation:
1. Department of Pediatrics, Zeynep Kamil Maternity and Children’s Disease Training and Research Hospital, University of Health Sciences, Istanbul 34668, Turkey
Abstract
This study examined the distinctions between multisystem inflammatory syndrome associated with coronavirus disease 2019, Kawasaki disease, and infectious mononucleosis. These three inflammatory disorders have commonalities according to clinical and laboratory results, particularly in relation to eosinophil levels. In this retrospective, single-center study, we documented the examination records (acute phase reactants and complete blood count) and clinical and cardiological findings of 130 patients diagnosed with multisystem inflammatory syndrome, Kawasaki disease, and infectious mononucleosis. These patients were treated and received follow-up care in our hospital from March 12, 2020, to September 13, 2022, as per the hospital records. Statistical analyses were performed using NCSS 2007, version 1 software. Eosinopenia was more prevalent in children with multisystem inflammatory syndrome than in those with Kawasaki disease, who showed normal or elevated eosinophil counts. The eosinophil counts in patients with infectious mononucleosis typically fell within the normal range. Our study found no correlation between the eosinophil counts and cardiac involvement in pediatric patients with either condition. These findings indicate a higher prevalence of eosinopenia in patients with multisystem inflammatory syndrome, irrespective of cardiac involvement, than in those with Kawasaki disease. Despite similarities in clinical findings, Kawasaki disease and multisystem inflammatory syndrome in children necessitate further studies for distinct characteristic elucidation.
Subject
Pediatrics, Perinatology and Child Health
Reference50 articles.
1. Owens, A.M., and Plewa, M.C. (2023, June 26). Kawasaki disease, StatPearls, Available online: https://www.ncbi.nlm.nih.gov/books/NBK537163/.
2. Diagnosis, treatment, and long-term management of Kawasaki disease: A scientific statement for health professionals from the American Heart Association;McCrindle;Circulation,2017
3. Epidemiology of COVID-19 among children in China;Dong;Pediatrics,2020
4. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults;Ludvigsson;Acta Paediatr.,2020
5. Hyperinflammatory shock in children during COVID-19 pandemic;Riphagen;Lancet,2020