Exploring the Multifaceted Nexus of Uric Acid and Health: A Review of Recent Studies on Diverse Diseases-Reference-Cited by-同舟云学术

Exploring the Multifaceted Nexus of Uric Acid and Health: A Review of Recent Studies on Diverse Diseases

Published:2023-10-13 Issue:10 Volume:13 Page:1519
ISSN:2218-273X
Container-title:Biomolecules
language:en
Short-container-title:Biomolecules

Author:

Kuwabara Masanari¹^ORCID,Fukuuchi Tomoko²,Aoki Yuhei³^ORCID,Mizuta Einosuke⁴,Ouchi Motoshi⁵⁶,Kurajoh Masafumi⁷^ORCID,Maruhashi Tatsuya⁸,Tanaka Atsushi⁹^ORCID,Morikawa Nagisa¹⁰¹¹,Nishimiya Kensuke¹²,Akashi Naoyuki¹³^ORCID,Tanaka Yoshihiro¹⁴^ORCID,Otani Naoyuki¹⁵,Morita Mihoko¹⁶,Miyata Hiroshi¹⁷,Takada Tappei¹⁷^ORCID,Tsutani Hiroshi¹⁸,Ogino Kazuhide¹⁹,Ichida Kimiyoshi²⁰^ORCID,Hisatome Ichiro²¹,Abe Kohtaro²²

Affiliation:

1. Department of Cardiology, Toranomon Hospital, 2-2-2-Toranomon, Minato, Tokyo 105-8470, Japan

2. Laboratory of Biomedical and Analytical Sciences, Faculty of Pharma-Science, Teikyo University, Itabashi, Tokyo 173-8605, Japan

3. Department of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Takamatsu 761-0793, Kagawa, Japan

4. Department of Cardiology, Sanin Rosai Hospital, Yonago 683-8605, Tottori, Japan

5. Department of Health Promotion in Nursing and Midwifery, Innovative Nursing for Life Course, Graduate School of Nursing, Chiba University, Chiba 260-8672, Chiba, Japan

6. Department of Pharmacology and Toxicology, School of Medicine, Dokkyo Medical University, Mibu 321-0293, Tochigi, Japan

7. Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka Metropolitan University, Osaka 5454-8585, Osaka, Japan

8. Department of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Hiroshima, Japan

9. Department of Cardiovascular Medicine, Saga University, Saga 849-8501, Saga, Japan

10. Division of Cardio-Vascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, Fukuoka, Japan

11. Department of Community Medicine, Kurume University School of Medicine, Kurume 830-0011, Fukuoka, Japan

12. Department of Cardiovascular Medicine, Tohoku University Hospital, Sendai 980-8574, Miyagi, Japan

13. Division of Cardiovascular Medicine, Jichi Medical University Saitama Medical Center, Saitama 330-8503, Saitama, Japan

14. Division of Epidemiology, Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka 420-0881, Shizuoka, Japan

15. Cardiovascular Center, Dokkyo Medical University Nikko Medical Center, Nikko 321-1298, Tochigi, Japan

16. Department of Hematology and Oncology, University of Fukui Hospital, Eiheiji 910-1193, Fukui, Japan

17. Department of Pharmacy, The University of Tokyo Hospital, Bunkyo, Tokyo 113-8655, Japan

18. National Hospital Organization Awara Hospital, Awara 910-4272, Fukui, Japan

19. Department of Cardiology, Japanese Red Cross Tottori Hospital, Tottori 680-8517, Tottori, Japan

20. Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan

21. National Hospital Organization Yonago Medical Center, Yonago 683-0006, Tottori, Japan

22. Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Fukuoka, Japan

Abstract

The prevalence of patients with hyperuricemia or gout is increasing worldwide. Hyperuricemia and gout are primarily attributed to genetic factors, along with lifestyle factors like consuming a purine-rich diet, alcohol and/or fructose intake, and physical activity. While numerous studies have reported various comorbidities linked to hyperuricemia or gout, the range of these associations is extensive. This review article focuses on the relationship between uric acid and thirteen specific domains: transporters, genetic factors, diet, lifestyle, gout, diabetes mellitus, metabolic syndrome, atherosclerosis, hypertension, kidney diseases, cardiovascular diseases, neurological diseases, and malignancies. The present article provides a comprehensive review of recent developments in these areas, compiled by experts from the Young Committee of the Japanese Society of Gout and Uric and Nucleic Acids. The consolidated summary serves to enhance the global comprehension of uric acid-related matters.

Funder

JSPS KAKENHI Grant

Toranomon Hospital Grant

Publisher

MDPI AG

Subject

Molecular Biology,Biochemistry

Link

https://www.mdpi.com/2218-273X/13/10/1519/pdf

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