Recombinant Pseudorabies Virus Usage in Vaccine Development against Swine Infectious Disease
Author:
Zhou Mo1ORCID, Abid Muhammad2ORCID, Cao Shinuo1, Zhu Shanyuan1
Affiliation:
1. Jiangsu Key Laboratory for High-Tech Research and Development of Veterinary Biopharmaceuticals, Engineering Technology Research Center for Modern Animal Science and Novel Veterinary Pharmaceutic Development, Jiangsu Agri-Animal Husbandry Vocational College, Taizhou 225306, China 2. Viral Oncogenesis Group, The Pirbright Institute, Ash Road Pirbright, Woking, Surrey GU24 0NF, UK
Abstract
Pseudorabies virus (PRV) is the pathogen of pseudorabies (PR), which belongs to the alpha herpesvirus subfamily with a double stranded DNA genome encoding approximately 70 proteins. PRV has many non-essential regions for replication, has a strong capacity to accommodate foreign genes, and more areas for genetic modification. PRV is an ideal vaccine vector, and multivalent live virus-vectored vaccines can be developed using the gene-deleted PRV. The immune system continues to be stimulated by the gene-deleted PRVs and maintain a long immunity lasting more than 4 months. Here, we provide a brief overview of the biology of PRV, recombinant PRV construction methodology, the technology platform for efficiently constructing recombinant PRV, and the applications of recombinant PRV in vaccine development. This review summarizes the latest information on PRV usage in vaccine development against swine infectious diseases, and it offers novel perspectives for advancing preventive medicine through vaccinology.
Funder
key project of Jiangsu Province’s Key Research and Development Plan project of Jiangsu Agri-animal Husbandry Vocational College Natural Science Research Project of Higher Education of Jiangsu Province Qing Lan Project of Jiangsu Province
Subject
Virology,Infectious Diseases
Reference71 articles.
1. Novel pseudorabies virus variant with defects in TK, gE and gI protects growing pigs against lethal challenge;Hu;Vaccine,2015 2. Zhao, X., Tong, W., Song, X., Jia, R., Li, L., Zou, Y., He, C., Liang, X., Lv, C., and Jing, B. (2018). Antiviral Effect of Resveratrol in Piglets Infected with Virulent Pseudorabies Virus. Viruses, 10. 3. Yao, J., Li, J., Gao, L., He, Y., Xie, J., Zhu, P., Zhang, Y., Zhang, X., Duan, L., and Yang, S. (2022). Epidemiological Investigation and Genetic Analysis of Pseudorabies Virus in Yunnan Province of China from 2017 to 2021. Viruses, 14. 4. Zheng, H.H., Fu, P.F., Chen, H.Y., and Wang, Z.Y. (2022). Pseudorabies Virus: From Pathogenesis to Prevention Strategies. Viruses, 14. 5. Comparative genomic analyses of a virulent pseudorabies virus and a series of its in vitro passaged strains;Ye;Virol. J.,2018
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|