The Profile of Bacterial Infections in a Burn Unit during and after the COVID-19 Pandemic Period

Author:

Musuroi Corina12,Musuroi Silvia-Ioana3,Baditoiu Luminita4ORCID,Crainiceanu Zorin5ORCID,Muntean Delia12ORCID,Voinescu Adela123,Izmendi Oana13ORCID,Sirmon Alexandra46,Licker Monica12ORCID

Affiliation:

1. Multidisciplinary Research Center of Antimicrobial Resistance, Microbiology Department, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania

2. Microbiology Laboratory, “Pius Brinzeu” County Clinical Emergency Hospital, 300723 Timisoara, Romania

3. Doctoral School, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timisoara, Romania

4. Epidemiology Department, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania

5. Department of Plastic Surgery, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania

6. Epidemiology Department, “Pius Brinzeu” County Clinical Emergency Hospital, 300723 Timisoara, Romania

Abstract

Infections represent a major complication for burn-injured patients. The aim of this study was to highlight the changes in the incidence and antimicrobial resistance of bacterial strains isolated from burn patients, at the end of the COVID-19 pandemic, in relation to the antibiotics used during the pandemic. A comparative analysis of the demographic data and the microorganisms identified in the clinical samples of two groups of burn patients admitted to a university hospital in Romania was carried out. The first group consisted of 48 patients and the second of 69 patients, hospitalized in January–August 2020 and 2023, respectively. The bacterial species with the highest incidence were S. aureus, A. baumannii, Pseudomonas spp. The significant changes between 2023 and 2020 are reflected in the increase in the frequency of non-fermentative Gram-negative bacteria, especially S. maltophilia, and the increase in antimicrobial resistance of Pseudomonas and Klebsiella spp. Klebsiella spp. did not change in frequency (7%), but there was a significant increase in the incidence of K. pneumoniae strains with pan-drug resistant behaviour to antibiotics (40%), including colistin. The phenomenon can be explained by the selection of specimens carrying multiple resistance genes, as a result of antibiotic treatment during the COVID-19 period. The post-pandemic antimicrobial resistance detected in burn patients indicates the need for permanent surveillance of the resistance trends, primarily due to the limited therapeutic options available for these patients.

Publisher

MDPI AG

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