Six Long-Standing Questions about Antibiotic Prophylaxis in Surgery

Author:

Sartelli Massimo1,Boermeester Marja A.2ORCID,Cainzos Miguel3,Coccolini Federico4,de Jonge Stijn W.2,Rasa Kemal5ORCID,Dellinger E. Patchen6ORCID,McNamara Deborah A.7ORCID,Fry Donald E.8,Cui Yunfeng9,Delibegovic Samir10,Demetrashvili Zaza11ORCID,De Simone Belinda12ORCID,Gkiokas George13ORCID,Hardcastle Timothy C.14ORCID,Itani Kamal M. F.15,Isik Arda16ORCID,Labricciosa Francesco Maria17,Lohsiriwat Varut18,Marwah Sanjay19,Pintar Tadeja20,Rickard Jennifer21,Shelat Vishal G.22ORCID,Catena Fausto23ORCID,Barie Philip S.24ORCID

Affiliation:

1. Department of Surgery, Macerata Hospital, 62100 Macerata, Italy

2. Department of Surgery, Amsterdam University Medical Center, University of Amsterdam, 1105AZ Amsterdam, The Netherlands

3. Department of Surgery, Hospital Clínico Universitario, 15706 Santiago de Compostela, Spain

4. Department of Emergency and Trauma Surgery, Pisa University Hospital, University of Pisa, 55126 Pisa, Italy

5. Department of Surgery, Anadolu Medical Center, 41200 Kocaeli, Turkey

6. Department of Surgery, University of Washington, Seattle, WA 98195, USA

7. Department of Colorectal Surgery, Beaumont Hospital, D09V2N0 Dublin, Ireland

8. Department of Surgery, Northwestern University, Chicago, IL 60208, USA

9. Department of Surgery, Tianjin Nankai Hospital, Nankai Clinical School of Medicine, Tianjin Medical University, Tianjin 300100, China

10. Department of Surgery, University Clinical Center of Tuzla, 75000 Tuzla, Bosnia and Herzegovina

11. Department General Surgery, Kipshidze Central University Hospital, Tbilisi 0162, Georgia

12. Department of Emergency and Metabolic Minimally Invasive Surgery, Centre Hospitalier Intercommunal de Poissy/Saint Germain en Laye, 78300 Poissy CEDEX, France

13. Second Department of Surgery, Aretaieion University Hospital, National and Kapodistrian University of Athens, 10679 Athens, Greece

14. Department of Surgery, Nelson R. Mandela School of Clinical Medicine, University of KwaZulu-Natal, Mayville 4058, South Africa

15. Department of Surgery, VA Boston Health Care System, Boston University and Harvard Medical School, Boston, MA 02118, USA

16. Division of General Surgery, School of Medicine, Istanbul Medeniyet University, 34700 Istanbul, Turkey

17. Global Alliance for Infections in Surgery, 62100 Macerata, Italy

18. Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand

19. Department of Surgery, BDS Post-Graduate Institute of Medical Sciences, Rohtak 124001, India

20. Department of Abdominal Surgery, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia

21. Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA

22. Department of Hepato-Pancreatic-Biliary Surgery, Tan Tok Seng Hospital, Singapore 308433, Singapore

23. Department of Surgery, “Bufalini” Hospital, 47023 Cesena, Italy

24. Department of Surgery, Weill Cornell Medicine, E. Northport, New York, NY 11731, USA

Abstract

Surgical site infections (SSIs) are the most common adverse event occurring in surgical patients. Optimal prevention of SSIs requires the bundled integration of a variety of measures before, during, and after surgery. Surgical antibiotic prophylaxis (SAP) is an effective measure for preventing SSIs. It aims to counteract the inevitable introduction of bacteria that colonize skin or mucosa into the surgical site during the intervention. This document aims to guide surgeons in appropriate administration of SAP by addressing six key questions. The expert panel identifies a list of principles in response to these questions that every surgeon around the world should always respect in administering SAP.

Publisher

MDPI AG

Subject

Pharmacology (medical),Infectious Diseases,Microbiology (medical),General Pharmacology, Toxicology and Pharmaceutics,Biochemistry,Microbiology

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