Abstract
Polymorphism (rs1805086), c.458A>G, p.Lys(K)153Arg(R), (K153R) of the myostatin gene (MSTN) has been associated with a skeletal muscle phenotype (hypertrophic response in muscles due to strength training). However, there are not enough reliable data to demonstrate whether MSTN rs1805086 K and R allelic variants are valid genetic factors that can affect the strength phenotype of athletes’ skeletal muscles. The aim is to conduct a systematic review and meta-analysis of the association of MSTN rs1805086 polymorphism with the strength phenotype of athletes. This study analyzed 71 research articles on MSTN and performed a meta-analysis of MSTN K153R rs1805086 polymorphism in strength-oriented athletes and a control (non-athletes) group. It was found that athletes in the strength-oriented athlete group had a higher frequency of the R minor variant than that in the control group (OR = 2.02, P = 0.05). Thus, the obtained results convincingly demonstrate that there is an association between the studied polymorphism and strength phenotype of athletes; therefore, further studies on this association are scientifically warranted.
Funder
Plekhanov Russian University of Economics
Subject
Genetics (clinical),Genetics
Reference74 articles.
1. Gene powered? Where to go from heritability (H-2) in muscle strength and power?;Exerc. Sport Sci. Rev.,2004
2. The effect of training volume and intensity on improvements in muscular strength and size in resistance-trained men;Physiol. Rep.,2015
3. Myostatin and the skeletal muscle atrophy and hypertrophy signaling pathways;Cell. Mol. Life Sci.,2014
4. Myostatin: Genetic variants, therapy and gene doping;Braz. J. Pharm. Sci.,2012
5. Acute Loading and Aging Effects on Myostatin Pathway Biomarkers in Human Skeletal Muscle After Three Sequential Bouts of Resistance Exercise;J. Gerontol. Ser. A-Biol. Sci. Med. Sci.,2011
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献