Ridge Preservation Using a Novel Enzyme-Treated Xenograft. A Preliminary Retrospective Histomorphometric Investigation

Abstract

The use of xenografts to preserve the post-extraction alveolar ridge is an established and effective procedure. Recently, a novel freeze-dried, enzyme-deantigenic equine bone (EDEB) particulate combined with a hydrogel carrier (Exur®) containing ascorbic acid has been developed (EDEBEX). The aim of this study was to preliminarily investigate histomorphometric and early implant survival outcomes following the graft of EDEBEX in post-extractive sockets. Records of patients who underwent ridge preservation using EDEBEX followed by two-step implant placement were retrospectively collected and analyzed. Newly Formed Bone (NFB) and Residual Biomaterial (RB) at the implant placement site were measured through histomorphometric analysis, and early Marginal Bone Loss (MBL) for implants was calculated at the final follow-up. Records concerned 13 patients (nine women and four men, average age 54.1 ± 9.5 years). The 13 sockets were considered healed 4.5 ± 2.6 months (mean ± SD) after grafting, with NFB and RB values of 43.2 ± 22.1% and 8.8 ± 5.9%, respectively. 8.4 ± 5.8 months after implant placement, the median MBL was 0.20 [0.00–0.45] mm. No correlation was observed between MBL and NFB. EDEBEX grafted in post-extractive sockets for ridge preservation seems to allow for new bone formation with satisfactory implant outcomes. Future prospective studies are necessary to confirm these preliminary findings.