Anti-Cancer Properties of Flaxseed Proteome

Author:

Merkher Yulia12ORCID,Kontareva Elizaveta1ORCID,Alexandrova Anastasia1,Javaraiah Rajesha3ORCID,Pustovalova Margarita14,Leonov Sergey145ORCID

Affiliation:

1. School of Biological and Medical Physics, Moscow Institute of Physics and Technology, Dolgoprudny 141700, Moscow Region, Russia

2. Faculty of Biomedical Engineering, Technion–Israel Institute of Technology, Haifa 3200003, Israel

3. Department of Biochemistry, Yuvaraja’s College, University of Mysore Mysuru, Karnataka 570005, India

4. State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency (SRC-FMBC), Moscow 123098, Russia

5. Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino 142290, Moscow Region, Russia

Abstract

Flaxseed has been recognized as a valuable source of nutrients and bioactive compounds, including proteins that possess various health benefits. In recent years, studies have shown that flaxseed proteins, including albumins, globulins, glutelin, and prolamins, possess anti-cancer properties. These properties are attributed to their ability to inhibit cancer cell proliferation, induce apoptosis, and interfere with cancer cell signaling pathways, ultimately leading to the inhibition of metastasis. Moreover, flaxseed proteins have been reported to modulate cancer cell mechanobiology, leading to changes in cell behavior and reduced cancer cell migration and invasion. This review provides an overview of the anti-cancer properties of flaxseed proteins, with a focus on their potential use in cancer treatment. Additionally, it highlights the need for further research to fully establish the potential of flaxseed proteins in cancer therapy.

Funder

Russian Science Foundation

Publisher

MDPI AG

Subject

Clinical Biochemistry,Molecular Biology,Biochemistry,Structural Biology

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