Affiliation:
1. Department of Pharmaceutical Sciences, School of Pharmacy, University of Jordan, Amman 11942, Jordan
Abstract
Matrix metalloproteinases (MMPs) belong to a family of zinc-dependent proteolytic metalloenzymes. MMP-9, a member of the gelatinase B family, is characterized as one of the most intricate MMPs. The crucial involvement of MMP-9 in extracellular matrix (ECM) remodeling underscores its significant correlation with each stage of cancer pathogenesis and progression. The design and synthesis of MMP-9 inhibitors is a potentially attractive research area. Unfortunately, to date, there is no effective MMP-9 inhibitor that passes the clinical trials and is approved by the FDA. This review primarily focuses on exploring the diverse strategies employed in the design and advancement of MMP-9 inhibitors, along with their anticancer effects and selectivity. To illuminate the essential structural characteristics necessary for the future design of novel MMP-9 inhibitors, the current narrative review highlights several recently discovered MMP-9 inhibitors exhibiting notable selectivity and potency.
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference166 articles.
1. Centers for Disease Control and Prevention (2023, July 09). National Centers for Health Statistics National Centers for Health Statistics, Available online: http://www.cdc.gov/nchs/fastats/cancer.htm.
2. The Extracellular Matrix Modulates the Hallmarks of Cancer;Pickup;EMBO Rep.,2014
3. Chapter One—Biochemical and Biological Attributes of Matrix Metalloproteinases;Khalil;Progress in Molecular Biology and Translational Science,2017
4. Matrix Metalloproteinases: Regulators of the Tumor Microenvironment;Kessenbrock;Cell,2010
5. Seesaw of Matrix Metalloproteinases (MMPs);Kapoor;J. Cancer Res. Ther.,2016
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献