The Era of the FLips: How Spike Mutations L455F and F456L (and A475V) Are Shaping SARS-CoV-2 Evolution-Reference-Cited by-同舟云学术

The Era of the FLips: How Spike Mutations L455F and F456L (and A475V) Are Shaping SARS-CoV-2 Evolution

Published:2023-12-19 Issue:1 Volume:16 Page:3
ISSN:1999-4915
Container-title:Viruses
language:en
Short-container-title:Viruses

Author:

Focosi Daniele¹^ORCID,Spezia Pietro Giorgio²^ORCID,Gueli Federico³,Maggi Fabrizio²^ORCID

Affiliation:

1. North-Western Tuscany Blood Bank, Pisa University Hospital, 56124 Pisa, Italy

2. National Institute for Infectious Diseases “Lazzaro Spallanzani” IRCCS, 00149 Rome, Italy

3. Independent Researcher, 22100 Como, Italy

Abstract

Convergent evolution of the SARS-CoV-2 Spike protein has been mostly driven by immune escape, in particular by escape to the viral infection-neutralizing antibodies (nAbs) elicited by previous infections and/or vaccinations [...]

Publisher

MDPI AG

Subject

Virology,Infectious Diseases

Link

https://www.mdpi.com/1999-4915/16/1/3/pdf

Reference16 articles.

1. Focosi, D., Quiroga, R., McConnell, S., Johnson, M.C., and Casadevall, A. (2023). Convergent evolution in SARS-CoV-2 Spike creates a variant soup from which new COVID-19 waves emerge. Int. J. Mol. Sci., 24.

2. Kosugi, Y., Plianchaisuk, A., Putri, O., Uriu, K., Kaku, Y., Alfredo A Hinay, J., Chen, L., Kuramochi, J., Sadamasu, K., and Yoshimura, K. (2023). Virological characteristics of the SARS-CoV-2 Omicron HK.3 variant harboring the “FLip” substitution. bioRxiv.

3. Jian, F., Feng, L., Yang, S., Yu, Y., Wang, L., Song, W., Yisimayi, A., Chen, X., Xu, Y., and Wang, P. (2023). Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455–456 synergistically enhances antibody evasion and ACE2 binding. bioRxiv.

4. Key mutations in the spike protein of SARS-CoV-2 affecting neutralization resistance and viral internalization;Wang;J. Med. Virol.,2023

5. Generation of SARS-CoV-2 escape mutations by monoclonal antibody therapy;Nutalai;Nat. Comm.,2023

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