Chemical and Biological Evaluation of Amazonian Medicinal Plant Vouacapoua americana Aubl

Author:

Çiçek Serhat SezaiORCID,Pfeifer Barbosa Anna Laís,Wenzel-Storjohann Arlette,Segovia Jorge Federico Orellana,Bezerra Roberto Messias,Sönnichsen FrankORCID,Zidorn ChristianORCID,Kanzaki Isamu,Tasdemir DenizORCID

Abstract

Vouacapoua americana (Fabaceae) is an economically important tree in the Amazon region and used for its highly resistant heartwood as well as for medicinal purposes. Despite its frequent use, phytochemical investigations have been limited and rather focused on ecological properties than on its pharmacological potential. In this study, we investigated the phytochemistry and bioactivity of V. americana stem bark extract and its constituents to identify eventual lead structures for further drug development. Applying hydrodistillation and subsequent GC-MS analysis, we investigated the composition of the essential oil and identified the 15 most abundant components. Moreover, the diterpenoids deacetylchagresnone (1), cassa-13(14),15-dien-oic acid (2), isoneocaesalpin H (3), (+)-vouacapenic acid (4), and (+)-methyl vouacapenate (5) were isolated from the stem bark, with compounds 2 and 4 showing pronounced effects on Methicillin-resistant Staphylococcus aureus and Enterococcus faecium, respectively. During the structure elucidation of deacetylchagresnone (1), which was isolated from a natural source for the first time, we detected inconsistencies regarding the configuration of the cyclopropane ring. Thus, the structure was revised for both deacetylchagresnone (1) and the previously isolated chagresnone. Following our works on Copaifera reticulata and Vatairea guianensis, the results of this study further contribute to the knowledge of Amazonian medicinal plants.

Funder

Federal District Funding Agency/FAP DF, Brazil

Publisher

MDPI AG

Subject

Plant Science,Ecology,Ecology, Evolution, Behavior and Systematics

Reference31 articles.

1. (2022, November 14). Vouacapoua Aubl. Available online: http://www.worldfloraonline.org/taxon/wfo-4000040438.

2. Germinaçao de sementes de espécies amazônicas: Acapu (Vouacapoua americana Aubl.);Cruz;Comun. Técnico Embrapa,2016

3. Rios, M.N.D.S., and Pastore Junior, F. (2011). Plantas da Amazônia: 450 Espécies de Uso Geral, Universidade de Brasília.

4. Kukachka, B.F. (1970). Properties of Imported Tropical Woods.

5. Áreas prioritárias na Amazônia para conservaçao dos recursos genéticos de espécies florestais nativas: Fase preliminar;Leite;Acta Bot. Bras.,1993

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3