Abstract
Fibrosis is defined as the excessive deposition of extracellular matrix (ECM) proteins in the interstitium. It is an essential pathological response to chronic inflammation. ECM protein deposition is initially protective and is critical for wound healing and tissue regeneration. However, pathological cardiac remodeling in excessive and continuous tissue damage with subsequent ECM deposition results in a distorted organ architecture and significantly impacts cardiac function. In this review, we summarized and discussed the histologic features of cardiac fibrosis with the signaling factors that control it. We evaluated the origin and characteristic markers of cardiac fibroblasts. We also discussed lymphatic vessels, which have become more important in recent years to improve cardiac fibrosis.
Funder
Japan Society for the Promotion of Science
JAPAN FOUNDATION FOR APPLIED ENZYMOLOGY
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference241 articles.
1. Heart failure drug treatment;Lancet,2019
2. Cardiac fibrosis;Cardiovasc. Res.,2020
3. Extracellular matrix-cell interactions: Focus on therapeutic applications;Cell Signal,2020
4. Extracellular matrix remodeling and cardiac fibrosis;Matrix Biol.,2018
5. Inflammatory Cardiomyopathy: A Current View on the Pathophysiology, Diagnosis, and Treatment;Biomed. Res. Int.,2016
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