Diffuse Reflectance Spectroscopy of the Oral Mucosa: In Vivo Experimental Validation of the Precancerous Lesions Early Detection Possibility-Reference-Cited by-同舟云学术

Diffuse Reflectance Spectroscopy of the Oral Mucosa: In Vivo Experimental Validation of the Precancerous Lesions Early Detection Possibility

Published:2023-05-05 Issue:9 Volume:13 Page:1633
ISSN:2075-4418
Container-title:Diagnostics
language:en
Short-container-title:Diagnostics

Author:

Kolpakov Alexander V.¹^ORCID,Moshkova Anastasia A.¹,Melikhova Ekaterina V.¹,Sokolova Diana Yu.¹^ORCID,Muravskaya Natalia P.¹,Samorodov Andrey V.¹^ORCID,Kopaneva Nina O.²^ORCID,Lukina Galina I.²,Abramova Marina Ya.²^ORCID,Mamatsashvili Veta G.²^ORCID,Parshkov Vadim V.²^ORCID

Affiliation:

1. Faculty of Biomedical Engineering, Bauman Moscow State Technical University, Moscow 105005, Russia

2. Department of Therapeutic Dentistry and Diseases of the Oral Mucosa, Moscow State University of Medicine and Dentistry, Moscow 127473, Russia

Abstract

This article is devoted to the experimental validation of the possibility of early detection of precancerous lesions in the oral mucosa in vivo using diffuse reflectance spectroscopy in the wavelength range from 360 to 1000 nm. During the study, a sample of 119 patients with precancerous lesions has been collected and analyzed. As a result of the analysis, the most informative wavelength ranges were determined, in which the maximum differences in the backscattering spectra of lesions and intact tissues were observed, methods for automatic classification of backscattering spectra of the oral mucosa were studied, sensitivity and specificity values, achievable using diffuse reflectance spectroscopy for detecting hyperkeratosis on the tongue ventrolateral mucosa surface and buccal mucosa, were evaluated. As a result of preliminary experimental studies in vivo, the possibility of automatic detection of precancerous lesions of the oral mucosa surface using diffuse reflectance spectroscopy in the wavelength range from 500 to 900 nm with an accuracy of at least 75 percent has been shown.

Publisher

MDPI AG

Subject

Clinical Biochemistry

Link

https://www.mdpi.com/2075-4418/13/9/1633/pdf

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