Plasma 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels in Breast Cancer Risk in Mali: A Case

Plasma 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels in Breast Cancer Risk in Mali: A Case–Control Study

Published:2023-12-14 Issue:24 Volume:13 Page:3664
ISSN:2075-4418
Container-title:Diagnostics
language:en
Short-container-title:Diagnostics

Author:

Bissan Aboubacar D. T.¹²³^ORCID,Ly Madani⁴,Amegonou Awo Emmanuela H.³,Sidibe Fatoumata M.³⁵,Koné Bocary S.³,Barry Nènè Oumou K.⁶,Tall Madiné²,Timbiné Lassana G.²,Kouriba Bourèma²³^ORCID,Reynier Pascal⁷^ORCID,Ouzzif Zahra¹

Affiliation:

1. Biochemistry, Metabolic and Molecular Unit, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University of Rabat, Rabat 10100, Morocco

2. Charles-Merieux Center for Infectiology (CMIC) of Bamako, Bamako BPE2283, Mali

3. Biology Teaching and Research Department, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako BPE423, Mali

4. University Hospital of Luxembourg, Bamako BPE91094, Mali

5. University Hospital of Point G of Bamako, Bamako BPE91093, Mali

6. Pharmaceutical Biochemistry Laboratory, Cheikh Anta Diop University of Dakar, Dakar BP 5005, Senegal

7. Department of Biochemistry and Molecular Biology, University Hospital of Angers, 49933 Angers, France

Abstract

(1) Background: Breast cancer is the most prevalent cancer found in women in Mali. The aim of the current study was to determine the association between metabolites circulating in the blood, 25(OH)D and 1,25(OH)2D, and vitamin D levels with the risk of breast cancer in Malian women. (2) Methods: We conducted a prospective case–control study from August 2021 to March 2022. Control subjects were matched to cases according to age (within 5 years). The patients’ clinical stage was determined by the oncologist according to the tumour–nodes–metastasis (TNM) classification system. (3) Results: We observed no differences in the mean 25(OH)D (p = 0.221) and 1,25(OH)2D (p = 0.285) between cases and controls. However, our findings indicate a more pronounced inverse association in the first level of plasma 25(OH)D, while the risk function decreases at higher levels. This observation takes strength with 1,25(OH)2D by a significant association between the first quartile and breast cancer as a risk factor (p = 0.03; OR = 71.84; CI: 1.36–3785.34). (4) Conclusions: These outcomes showed a possible association between 25(OH)D and 1,25(OH)2D in decreasing the risk of breast cancer.

Publisher

MDPI AG

Subject

Clinical Biochemistry

Link

https://www.mdpi.com/2075-4418/13/24/3664/pdf

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