Cardiac Surgery Patients Have Reduced Vascularity and Structural Defects of the Retina Similar to Persons with Open-Angle Glaucoma

Author:

Vičaitė Gabija1,Barišauskaitė Liveta1ORCID,Bakstytė Viktorija1,Siesky Brent2,Verticchio Vercellin Alice2,Janulevičienė Ingrida1ORCID

Affiliation:

1. Medical Academy, Lithuanian University of Health Sciences, Eiveniu 2, LT-50161 Kaunas, Lithuania

2. Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

Abstract

(1) Background: Growing evidence suggests impairment of ocular blood flow in open-angle glaucoma (OAG) pathology, but little is known about the effect of an impaired cardiovascular supply on the structural and vascular parameters of the retina. This study aims to investigate the variations of these parameters in OAG patients compared to patients undergoing cardiac surgery (CS) with cardiopulmonary bypass. (2) Methods: Prospective observational study with 82 subjects (30 controls, 33 OAG patients, and 19 CS patients) who underwent ophthalmological assessment by swept-source OCT and CDI in one randomly selected eye. (3) Results: In the CS group, OA and SPCA PSV and EDV were significantly lower, OA and SPCA RI were significantly higher compared to the OAG and healthy subjects (p = 0.000–0.013), and SPCA EDV correlated with linear CDR (r = −0.508, p = 0.027). Temporal ONH sectors of GCL++ and GCL+ layers in the CS group did not differ significantly compared to the OAG patients (p = 0.085 and p = 0.220). The CS patients had significantly thinner GCL++ and GCL+ layers in the inner sectors (p = 0.000–0.038) compared to healthy subjects, and these layers correlated with the CRA PSV, EDV, and RI and SPCA PSV (p = 0.005–0.047). (4) Conclusions: CS patients had lower vascular and structural parameters in the ONH, and macula compared to the healthy controls that were similar to persons with OAG.

Publisher

MDPI AG

Reference35 articles.

1. The association between visual field reliability indices and cognitive impairment in glaucoma patients;Raman;J. Glaucoma,2019

2. Primary open angle glaucoma genetics: The common variants and their clinical associations;Trivli;Mol. Med. Rep.,2020

3. Optical Coherence Tomography and Glaucoma;Geevarghese;Annu. Rev. Vis. Sci.,2021

4. Wang, X., Wang, M., Liu, H., Mercieca, K., Prinz, J., Feng, Y., and Prokosch, V. (2023). The Association between Vascular Abnormalities and Glaucoma—What Comes First?. Int. J. Mol. Sci., 24.

5. Weinreb, R.F.N., Director, C., Greenfield, D.M., Gupta, N., Liebmann, J.M., Ritch, R., and Varma, R. (2015). The Role of Ocular Perfusion Pressure in Glaucoma, New York Eye and Ear Infirmary of Mount Sinai.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3