Diagnostic Performance of an Artificial Intelligence Model Based on Contrast-Enhanced Ultrasound in Patients with Liver Lesions: A Comparative Study with Clinicians

Author:

Urhuț Marinela-Cristiana1ORCID,Săndulescu Larisa Daniela2ORCID,Streba Costin Teodor234,Mămuleanu Mădălin45ORCID,Ciocâlteu Adriana2ORCID,Cazacu Sergiu Marian2ORCID,Dănoiu Suzana6

Affiliation:

1. Department of Gastroenterology, Emergency County Hospital of Craiova, Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania

2. Department of Gastroenterology, Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania

3. Department of Pulmonology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania

4. Oncometrics S.R.L., 200677 Craiova, Romania

5. Department of Automatic Control and Electronics, University of Craiova, 200585 Craiova, Romania

6. Department of Pathophysiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania

Abstract

Contrast-enhanced ultrasound (CEUS) is widely used in the characterization of liver tumors; however, the evaluation of perfusion patterns using CEUS has a subjective character. This study aims to evaluate the accuracy of an automated method based on CEUS for classifying liver lesions and to compare its performance with that of two experienced clinicians. The system used for automatic classification is based on artificial intelligence (AI) algorithms. For an interpretation close to the clinical setting, both clinicians knew which patients were at high risk for hepatocellular carcinoma (HCC), but only one was aware of all the clinical data. In total, 49 patients with 59 liver tumors were included. For the benign and malignant classification, the AI model outperformed both clinicians in terms of specificity (100% vs. 93.33%); still, the sensitivity was lower (74% vs. 93.18% vs. 90.91%). In the second stage of multiclass diagnosis, the automatic model achieved a diagnostic accuracy of 69.93% for HCC and 89.15% for liver metastases. Readers demonstrated greater diagnostic accuracy for HCC (83.05% and 79.66%) and liver metastases (94.92% and 96.61%) compared to the AI system; however, both were experienced sonographers. The AI model could potentially assist and guide less-experienced clinicians to discriminate malignant from benign liver tumors with high accuracy and specificity.

Funder

niversity of Medicine and Pharmacy of Craiova, Romania

Publisher

MDPI AG

Subject

Clinical Biochemistry

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