Extracorporeal Membrane Oxygenation (ECMO)-Associated Coagulopathy in Adults

Author:

Frantzeskaki Frantzeska1ORCID,Konstantonis Dimitrios1,Rizos Michail1,Kitsinelis Vasileios1,Skyllas Georgios1,Renieris Ioannis1,Doumani Maria1,Kolias Vasileios2ORCID,Kefalidi Eirini2,Angouras Dimitrios2ORCID,Tsantes Argyrios3,Tsangaris Iraklis1ORCID

Affiliation:

1. 2nd Critical Care Department, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 157 72 Athens, Greece

2. Department of Cardiac Surgery, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 157 72 Athens, Greece

3. Laboratory of Haematology, Blood Bank Unit, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 157 72 Athens, Greece

Abstract

Extracorporeal membrane oxygenation (ECMO) is used for the management of severe respiratory and cardiac failure and as a bridge to achieve definite treatment or transplantation. ECMO-associated coagulopathy (EAC) is a frequent complication leading to high rates of thrombosis or severe haemorrhage, contributing to morbidity and mortality among patients. Understanding the pathophysiology of EAC is substantial for effectively managing patients on ECMO. We analyse the underlying mechanism of EAC and discuss the monitoring of the coagulation profile, combining the viscoelastic point-of-care assays with the conventional coagulation laboratory tests.

Publisher

MDPI AG

Subject

Clinical Biochemistry

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