Chronic Thromboembolic Pulmonary Hypertension: An Update

Author:

Ruaro BarbaraORCID,Baratella ElisaORCID,Caforio Gaetano,Confalonieri PaolaORCID,Wade Barbara,Marrocchio CristinaORCID,Geri Pietro,Pozzan Riccardo,Andrisano Alessia Giovanna,Cova Maria Assunta,Cortale Maurizio,Confalonieri MarcoORCID,Salton FrancescoORCID

Abstract

Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare disease observed in a small proportion of patients after acute pulmonary embolism (PE). CTEPH has a high morbidity and mortality rate, related to the PH severity, and a poor prognosis, which mirrors the right ventricular dysfunction involvement. Pulmonary endarterectomy (PEA) reduces pulmonary vascular resistance, making it the treatment of choice and should be offered to operable CTEPH patients, as significant symptomatic and prognostic improvement has been observed. Moreover, these patients may also benefit from the advances made in surgical techniques and pulmonary hypertension-specific medication. However, not all patients are eligible for PEA surgery, as some have either distal pulmonary vascular obstruction and/or significant comorbidities. Therefore, surgical candidates should be carefully selected by an interprofessional team in expert centers. This review aims at making an overview of the risk factors and latest developments in diagnostic tools and treatment options for CTEPH.

Publisher

MDPI AG

Subject

Clinical Biochemistry

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