Affiliation:
1. College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, Seongnam 13488, Republic of Korea
2. CHlabs Corporation, Seoul 07249, Republic of Korea
3. Chong Kun Dang Healthcare, Seoul 07249, Republic of Korea
Abstract
Cinnamomum cassia (cassia) is a tropical aromatic evergreen tree of the Lauraceae family well known for its fragrance and spicy flavor and widely used in Asian traditional medicine. It has recently garnered attention for its diverse potential health benefits, including anti-inflammatory, anti-cancer, and anti-diabetic properties. However, the gastroprotective effect of C. cassia, particularly against ethanol-induced gastric damage, remains unclear. We investigated the potential gastroprotective property of C. cassia and the underlying mechanisms of action in a rat model of ethanol-induced gastric injury. To assess its effectiveness, rats were fed C. cassia for a 14-day period prior to inducing gastric damage by oral administration of ethanol. Our results indicated that pre-treatment with C. cassia mitigated ethanol-induced gastric mucosal lesions and bleeding. Reduced gastric acid secretion and expression of acid secretion-linked receptors were also observed. Additionally, pretreatment with C. cassia led to decreased levels of inflammatory factors, including TNF-α, p-p65, and IκBα. Notably, C. cassia upregulated the expressions of HO1 and HSP90, with particular emphasis on the enhanced expression of PAS and MUC, the crucial gastric mucosa defense molecules. These findings suggest that C. cassia has protective effects on the gastric mucosa and can effectively reduce oxidative stress and inflammation.
Funder
National Research Foundation of Korea
Korea government
Subject
Food Science,Nutrition and Dietetics
Reference42 articles.
1. Chronic gastritis;Sipponen;Scand. J. Gastroenterol.,2015
2. Rutaecarpine ameliorates ethanol-induced gastric mucosal injury in mice by modulating genes related to inflammation, oxidative stress and apoptosis;Ren;Front. Pharmacol.,2020
3. Ren, S., Chen, B., Ma, Z., Hu, H., and Xie, Y. (2021). Polygonum hydropiper extract attenuates ethanol-induced gastric damage through antioxidant and anti-inflammatory pathways. Braz. J. Med. Biol. Res., 54.
4. Reactive carbonyl species scavengers—Novel therapeutic approaches for chronic diseases;Davies;Curr. Pharmacol. Rep.,2017
5. Oxidative stress: An essential factor in the pathogenesis of gastrointestinal mucosal diseases;Bhattacharyya;Physiol. Rev.,2014