Affiliation:
1. School of Exercise and Health, Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai 200438, China
2. State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, China
Abstract
Adipose tissue undergoes changes with aging, leading to increased adiposity, inflammatory cell infiltration, reduced angiogenesis, heightened oxidative stress, and alterations in its metabolic function. Regular exercise has been recognized as a powerful intervention that can positively influence adipose tissue health and mitigate the effects of aging. However, the molecular mechanisms underlying the benefits of regular exercise on aging adipose tissue function remain poorly understood. Adipokines released through regular exercise play a potential role in mitigating adipose tissue aging, enhancing the metabolism of glucose and lipids, reducing inflammation and fibrosis, and promoting fat browning and thermogenesis. This review comprehensively summarizes the benefits of regular exercise in addressing the age-related decline in adipose tissue function. Utilizing relevant examples of this approach, we address the possibility of designing therapeutic interventions based on these molecular mechanisms.
Funder
National Natural Science Foundation of China
National Key R&D Program of China
Shanghai “Science and Technology Innovation Action Plan” Social Development Science and Technology Reach Project
Shanghai Municipal Science and Technology Committee of Shanghai outstanding academic leaders plan
esearch project of Shanghai University of Sport
Cited by
2 articles.
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