Abstract
Ubiquitin-like proteins (Ubls) are involved in a variety of biological processes through the modification of proteins. Dysregulation of Ubl modifications is associated with various diseases, especially cancer. Ubiquitin-like protein 3 (UBL3), a type of Ubl, was revealed to be a key factor in the process of small extracellular vesicle (sEV) protein sorting and major histocompatibility complex class II ubiquitination. A variety of sEV proteins that affects cancer properties has been found to interact with UBL3. An increasing number of studies has implied that UBL3 expression affects cancer cell growth and cancer prognosis. In this review, we provide an overview of the relationship between various Ubls and cancers. We mainly introduce UBL3 and its functions and summarize the current findings of UBL3 and examine its potential as a therapeutic target in cancers.
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference139 articles.
1. Expanding the Ubiquitin Code through Post-Translational Modification;Herhaus;EMBO Rep.,2015
2. Modification of Proteins by Ubiquitin and Ubiquitin-like Proteins;Kerscher;Annu. Rev. Cell Dev. Biol.,2006
3. The Role of Ubiquitination in Apoptosis and Necroptosis;Roberts;Cell Death Differ.,2022
4. Hwang, J.-T., Lee, A., and Kho, C. (2022). Ubiquitin and Ubiquitin-like Proteins in Cancer, Neurodegenerative Disorders, and Heart Diseases. Int. J. Mol. Sci., 23.
5. MUBs, a Family of Ubiquitin-Fold Proteins That Are Plasma Membrane-Anchored by Prenylation;Downes;J. Biol. Chem.,2006