Biomaterial Inks from Peptide-Functionalized Silk Fibers for 3D Printing of Futuristic Wound-Healing and Sensing Materials
-
Published:2023-01-04
Issue:2
Volume:24
Page:947
-
ISSN:1422-0067
-
Container-title:International Journal of Molecular Sciences
-
language:en
-
Short-container-title:IJMS
Author:
Ceccarini Maria RacheleORCID, Palazzi Valentina, Salvati Raffaele, Chiesa IreneORCID, De Maria CarmeloORCID, Bonafoni StefaniaORCID, Mezzanotte Paolo, Codini MichelaORCID, Pacini LorenzoORCID, Errante FoscaORCID, Rovero PaoloORCID, Morabito AntoninoORCID, Beccari TommasoORCID, Roselli Luca, Valentini LucaORCID
Abstract
This study illustrates the sensing and wound healing properties of silk fibroin in combination with peptide patterns, with an emphasis on the printability of multilayered grids, and envisions possible applications of these next-generation silk-based materials. Functionalized silk fibers covalently linked to an arginine–glycine–aspartic acid (RGD) peptide create a platform for preparing a biomaterial ink for 3D printing of grid-like piezoresistors with wound-healing and sensing properties. The culture medium obtained from 3D-printed silk fibroin enriched with RGD peptide improves cell adhesion, accelerating skin repair. Specifically, RGD peptide-modified silk fibroin demonstrated biocompatibility, enhanced cell adhesion, and higher wound closure rates at lower concentration than the neat peptide. It was also shown that the printing of peptide-modified silk fibroin produces a piezoresistive transducer that is the active component of a sensor based on a Schottky diode harmonic transponder encoding information about pressure. We discovered that such biomaterial ink printed in a multilayered grid can be used as a humidity sensor. Furthermore, humidity activates a transition between low and high conductivity states in this medium that is retained unless a negative voltage is applied, paving the way for utilization in non-volatile organic memory devices. Globally, these results pave the way for promising applications, such as monitoring parameters such as human wound care and being integrated in bio-implantable processors.
Funder
Italian Ministry of Education, University and Research
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference40 articles.
1. Super Tough and Spontaneous Water-Assisted Autonomous Self-Healing Elastomer for Underwater Wearable Electronics;He;Adv. Sci.,2021 2. Liang, F.C., Jhuang, F.C., Fang, Y.H., Benas, J.S., Chen, W.C., Yan, Z.L., Lin, W.C., Su, C.J., Sato, Y., and Chiba, T. (2022). Synergistic Effect of Cation Composition Engineering of Hybrid cs1−xFAxPbBr3 Nanocrystals For Self-Healing Electronics Application. Adv. Mater., 2207617. accepted. 3. Su, C., Chen, Y., Tian, S., Lu, C., and Lv, Q. (2022). Natural Materials for 3D Printing and Their Applications. Gels, 8. 4. Silk fibroin biomaterials for tissue regenerations;Kun;Adv. Drug Deliv. Rev.,2013 5. Surprising strength of silkworm silk;Shao;Nature,2002
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|